Targeting AKAP79/150 in Human Disorders: An Emerging Opportunity for Future Therapies?

Abstract

A-kinase anchoring protein 79/150 (AKAP79/150) is an important scaffolding protein, which anchors various important proteins to locate in appropriate synaptic domains to regulate excitatory synaptic intensity. With sweeping advances in the biology of AKAP79/150 and its critical role in the pathophysiology of various human disorders, more and more evidence is breeding new opportunities for potential therapeutic intervention in an attempt to improve the clinical outcomes of those patients. Herein, we review the basic structure and main functions of AKAP79/150, focusing on the pathophysiological mechanisms of AKAP79/150 in different human disorders, with a particular emphasis on the inflammatory pain, epilepsy, and depression, to discuss their potential therapeutic intervention value in patients with those diseases.