Abstract:Nanoparticles (NPs) are a drug delivery system that can enable delivery of a drug to a targeted tissue. Previous studies have shown that the use of an adipose targeting sequence (ATS) peptide in conjunction with a drug in the form of a NP has the ability to selectively deliver the drug to mouse adipose tissues. The prohibitin protein located in adipose tissue is the target of ATS. Adipose tissue is a major source of the adipokine chemerin, a prohypertensive protein. Our laboratory has proven that liver derived… Show more
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