Abstract:Background
Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulation and strategies to ameliorate tau-disrupted spatial memory in terms of neural circuits still remain elusive.
Methods
To investigate the effect and mechanism of the cholinergic circuit in Alzheimer's disease-related hippocampal me… Show more
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