Targeted Worm Micelles

Dalhaimer, Paul; Engler, Adam J.; Parthasarathy, Ranganath; Discher, Dennis E.

doi:10.1021/bm049884v

Cited by 131 publications

(110 citation statements)

References 26 publications

(54 reference statements)

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“…It was verified that the ratio of hydrophilic or hydrophobic to total polymer mass reflects the ability of micelles to form several nanostructures, such as spherical micelles, cylindrical micelles, and polymersomes. [19][20][21] In this study, PLLA-b-PEG with different molecular weights of PLLA block were prepared and utilized to explore the optimal ratio of hydrophobic to total polymer mass for constructing cylindrical micelles. In a preliminary study, the micelles fabricated by the film-rehydration method [19][20][21] using PLLA (Mn 5K)-b-PEG (Mn 2K) led to mixed miceller structures with spherical and cylindrical shapes (data not shown).…”

Section: Resultsmentioning

confidence: 99%

“…[19][20][21] In this study, PLLA-b-PEG with different molecular weights of PLLA block were prepared and utilized to explore the optimal ratio of hydrophobic to total polymer mass for constructing cylindrical micelles. In a preliminary study, the micelles fabricated by the film-rehydration method [19][20][21] using PLLA (Mn 5K)-b-PEG (Mn 2K) led to mixed miceller structures with spherical and cylindrical shapes (data not shown). This is comparable with the PLLA (M n 3K)-b-PEG (M n 2K) that has been often used to produce nano-sized spherical micelles for drug delivery.…”

Section: Resultsmentioning

confidence: 99%

“…This property of rod-like micelles is assumed to cause extensive fragmentation of micelles. [19][20][21][30][31][32] It was observed that the rod-like micelles underwent rapid fragmentation during 6 -24 hours of incubation ( Figure 6). While, the length of worm-like micelles slowly decreased with time ( Figure 6), suggesting a relatively high resistance of worm-like micelles to mechanical shear stress.…”

Section: -29mentioning

confidence: 99%

“…[19][20][21] Furthermore, due to their flexible, long shapes, which reduce phagocytic clearance in body, 19 blood circulation (with improved blood stability) for up to 1 week, which may be longer than any other synthetic nanoparticle. [19][20][21] In particular, the relative broad surface area of the worm-like micelles present positive features for surface functionality.…”

Section: Introductionmentioning

confidence: 99%

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Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells

Lee¹,

Oh²,

Baik³

et al. 2010

Bulletin of the Korean Chemical Society

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In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self-assembly that consisted of a relatively long PLLA block (Mn 7K Daltons) at the core and a relatively short PEG block (Mn 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: -29mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells

Lee¹,

Oh²,

Baik³

et al. 2010

Bulletin of the Korean Chemical Society

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“…Understanding such charge effects may enable further advances in processes such as quantum dot growth within worm micelles. 14 Lastly, because of the stability of worm micelles and their surprising ability to enter cells when targeted, 28 block copolymer worm micelles are now finding applications in drug delivery. The hydrolytic degradation of poly(ethylene oxide)-poly(caprolactone)-based worm micelles has been demonstrated to be a viable option for the timed release of hydrophobic drugs.…”

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confidence: 99%

Block copolymer worm micelles in dilution: Mechanochemical metrics of robustness as a basis for novel linear assemblies

Vijayan

Discher

2006

J Polym Sci B Polym Phys

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Over the last decade, it has become increasingly clear that amphiphilic block copolymers composed of strongly segregating blocks will self-direct their assembly in water into the same basic aggregate structures found for small surfactants: spheres, cylinders, and vesicular membranes. [1][2][3] For each of these morphologies, the idealized packing parameter p 4 is readily determined by a comparison of the core volume per molecule to its interfacial area: p < 1/3 for spherical micelles, p ¼ 1/3 À 1/2 for cylindrical worm micelles, and p ¼ 1/2 À 1 for membrane-bound vesicles. This simple and widely used shape parameterization serves to show that worm micelles not only are an intermediate microphase but also occupy the narrowest sliver of the phase diagram: Dp sph ¼ 0.333 versus Dp wm ¼ 0.167 versus Dp ves ¼ 0.50. In other words, worm micelles not only require more carefully proportioned hydrophilic-to-hydrophobic block ratios to achieve stability but also are likely to be less stable than other morphologies. Indeed, although spherical micelles and vesicles of lipids and surfactants have been extensively characterized, there are relatively few studies and applications of lipid-or surfactantbased worm micelles, in part because stresses and thermal defects accumulate over the length of any embedded linear object and tend to disrupt it. Block copolymers lead to more robust assemblies and thus open up new opportunities.What block copolymers provide, of course, is a broadened choice of both the composition and molecular weight versus small amphiphiles. 2,5 The simplest strong segregation theory balances the interfacial tension against the chain elasticity and predicts that core diameter d of worm micelles will scale with molecular weight N of the hydrophobic block. Within experimental error, 6 the scaling iswhere a is the monomer size. To understand the implications of such scaling for chemical stability as well as mechanical stability, particularly in stirring, extrusion, and sonication, old and new theories of surfactancy and soft-matter stability can be invoked. First, recent studies of polymer vesicles and polymersomes have taught us that interfacial tension c, established at the semisolvated interface between the core and corona, is independent of N. 7 For a series of diblock copolymers composed of poly(ethylene oxide)

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