Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression

Lei, Yifeng; Hamada, Yo; Li, Jun; Cong, Liman; Wang, Nuoxin; Liu, Ying; Zheng, Wenfu; Jiang, Xingyu

doi:10.1016/j.jconrel.2016.03.023

Cited by 90 publications

(59 citation statements)

References 45 publications

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“…Ferritin can function as a ligand as well to target cells that highly express ferritin-internalizing receptors, such as Scara5 and TfR1237. Moreover, ferritin can be disassembled and reassembled by changing the pH to low or physiological, respectively, which facilitates drug loading and endows the protein with pH-triggered drug release properties, enabling discharge specifically upon uptake and lysosomal processing by the target cell238.…”

Section: Iron Metabolism As a Therapeutic Targetmentioning

confidence: 99%

Targeting iron metabolism in drug discovery and delivery

Crielaard

Lammers

Rivella

2017

Nat Rev Drug Discov

281

205

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Iron fulfils a central role in many essential biochemical processes in human physiology, which makes proper processing of iron crucial. Although iron metabolism is subject to relatively strict physiological control, in recent years numerous disorders, such as cancer and neurodegenerative diseases, have been linked to deregulated iron homeostasis. Because of its involvement in the pathogenesis of these diseases, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents will likely have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are often available.

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Section: Iron Metabolism As a Therapeutic Targetmentioning

confidence: 99%

Targeting iron metabolism in drug discovery and delivery

Crielaard

Lammers

Rivella

2017

Nat Rev Drug Discov

281

205

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“…The Ft-based NPs, thus, include a successful and healthy way of carrying neural drugs for new anticancer therapies. 39 Alginate also represents a green nanomedicine approach to decrease NP toxicity. For example, quinapyramine sulfate (QS)-supported sodium alginate NPs have been prepared to decrease unpleasant toxic effects of QS against the parasite Trypanosoma evansi, a causative factor of trypanosomosis.…”

mentioning

confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

440

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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“…In particular, nervous microenvironment has a crucial impact during the growth and metastasis of pancreatic cancer67. Perineural invasion is a prominent pathologic feature of pancreatic cancer6, which is considered as the foremost reason for the high tumour recurrence, severe neuropathic pain and poor patient survival of pancreatic cancer6.…”

mentioning

confidence: 99%

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

et al. 2017

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Pancreatic cancer is one of the deadliest human cancers, whose progression is highly dependent on the nervous microenvironment. The suppression of gene expression of nerve growth factor (NGF) may have great potential in pancreatic cancer treatment. Here we show that gold nanocluster-assisted delivery of siRNA of NGF (GNC–siRNA) allows efficient NGF gene silencing and pancreatic cancer treatment. The GNC–siRNA complex increases the stability of siRNA in serum, prolongs the circulation lifetime of siRNA in blood and enhances the cellular uptake and tumour accumulation of siRNA. The GNC–siRNA complex potently downregulates the NGF expression in Panc-1 cells and in pancreatic tumours, and effectively inhibits the tumour progression in three pancreatic tumour models (subcutaneous model, orthotopic model and patient-derived xenograft model) without adverse effects. Our study constitutes a straightforward but effective approach to inhibit pancreatic cancer via NGF knockdown, suggesting a promising therapeutic direction for pancreatic cancer.

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Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression

Cited by 90 publications

References 45 publications

Targeting iron metabolism in drug discovery and delivery

Targeting iron metabolism in drug discovery and delivery

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

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