Targeted tumor CT imaging using folic acid-modified PEGylated dendrimer-entrapped gold nanoparticles

Folic acid-conjugated chromium(III) doped nanoparticles consisting of mixed oxides of zinc, gallium and tin, and possessing near-infrared and long persistent phosphorescence for targeted imaging of cancer cells

“…To improve the biocompatibility, colloidal stability and functionalization of targeting, the ZGSC nanoparticles were first ammoniated by coating APTES via a condensation reaction, and then PEGylated by adding the bifunctional NH 2 -PEG-COOH. Further conjugation of the PEG-ZGSC with FA was carried out for tumor-targeted imaging application [26].…”

“…The mixture was heated in an oil bath pan at 93°C for 2 h, then heating up to 130°C. After 1 h, the n-butyl alcohol treated gel was dried in an oven at 130°C for 24 h. Finally, the obtained materials were annealed in air at 1100°C for 1 h. The synthesis of FA-ZGSC was modified from several previous publications [2,10,26], as shown in Scheme 1. The sintered ZGSC powders were ground for 30 min first, and then centrifuged at 10,000 rpm for 30 min to remove large size particles, and the supernatant was centrifuged at 13,000 rpm for 5 min to collect the precipitate.…”

Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles

“…Thanks to the unique PEGylation conjugation chemistry, FAtargeted Au DENPs can be synthesized for targeted CT imaging of an FAR-overexpressing tumor model [59]. On the basis of these prior studies, in this study we developed a-TOS-conjugated amines (Fig.…”

Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors

“…Our previous work has shown that dendrimer-entrapped AuNPs [19e23, 51,52] and Fe 3 O 4 NPs prepared via either controlled coprecipitation [53,54] or hydrothermal [15e17,55] approaches are able to be used as CT and MR contrast agents, respectively for molecular imaging applications. Dual mode MR/CT imaging functionality can be easily realized by assembly of dendrimerentrapped AuNPs onto preformed Fe 3 O 4 NPs [37] or by hydrothermal synthesis of Fe 3 O 4 /Au composite NPs [56,57].…”