Targeted treatments for immune dysregulation in inborn errors of immunity
Nadia Makkoukdji,
Valishti Pundit,
Matthew Wyke
et al.
Abstract:Primary immune regulatory disorders (PIRDs) constitute a subset of inborn errors of immunity and are characterized by lymphoproliferation, autoimmunity, malignancy, and infection. Unlike classical primary immune deficiencies, initial symptoms of PIRDs can manifest as autoimmunity such as cytopenias or enteropathy, which can often prove resistant to conventional treatments and occur years prior to the onset of infectious complications. Raising awareness about PIRDs among specialists and adopting a multidiscipli… Show more
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