“…In contrast, the economic incentives of the precision medicine that tries to tailor the treatment to the patient’s characteristics are still limited, especially for low-income countries [ 13 , 14 ]. Owing to these (mostly desired rather than real) benefits, BMP serves to standardize the oncological recommendations and procedures (e.g., [ 15 , 16 ]).…”
Identifying the most effective actionable molecules whose “smart” manipulation might selectively kill/slow down/stop the proliferation of cancer cells, with few side effects on the normal cells of the tissue, was for decades the single major objective of countless investigators [...]
“…In contrast, the economic incentives of the precision medicine that tries to tailor the treatment to the patient’s characteristics are still limited, especially for low-income countries [ 13 , 14 ]. Owing to these (mostly desired rather than real) benefits, BMP serves to standardize the oncological recommendations and procedures (e.g., [ 15 , 16 ]).…”
Identifying the most effective actionable molecules whose “smart” manipulation might selectively kill/slow down/stop the proliferation of cancer cells, with few side effects on the normal cells of the tissue, was for decades the single major objective of countless investigators [...]
Provided herein are novel combination of allosteric and orthosteric EGFR inhibitors, pharmaceutical compositions, use of such compounds in treating non-small-cell lung cancer, and processes for preparing such compounds.
Important Compound Classes.
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