Targeted Therapy for Kaposi Sarcoma

Sullivan, Ryan J.; Pantanowitz, Liron; Dezube, Bruce J.

doi:10.2165/00063030-200923020-00001

Cited by 35 publications

(35 citation statements)

References 60 publications

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“…Kaposi's sarcoma-associated herpes virus (KSHV), also known as human herpes virus 8 (HHV8), is the causal agent of Kaposi's sarcoma (KS) [23]. Seroprevalence studies have shown that a positive HHV8 serostatus is mainly associated with an HIV infection, but can also occur in HIV-negative individuals; however, the prevalence in this group is much lower.…”

Section: Discussionmentioning

confidence: 99%

Do fewer cases of Kaposi’s sarcoma in HIV-infected patients reflect a decrease in HHV8 seroprevalence?

Reinheimer

Allwinn

Stürmer

2011

Med Microbiol Immunol

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Infection with human herpes virus 8 (HHV8) is associated with development of Kaposi's sarcoma (KS); therefore also known as KS-associated herpes virus. KS is closely associated with human immunodeficiency virus (HIV) infection, and consequently HHV8 seroprevalence is higher in HIV-infected compared to HIV-negative patients. Currently, KS is rarely seen in clinical practice, which might be a consequence of an optimized anti-HIV treatment leading to an improved immunological status, or alternatively of a decrease in HHV8 prevalence. To determine the prevalence of HHV8 antibodies in HIV-positive compared to HIV-negative patients from the University Hospital Frankfurt/Main, Germany, and to compare our results with previously published data to illustrate trends in the spread of infection. Hundred serum samples each of HIV-positive and HIV-negative patients were analyzed for HHV8 antibodies by using an IgG immunofluorescence test. The overall HHV8 seroprevalence was 16% with no statistically significant gender-specific differences; however, the distribution between the HIV-infected patients and the HIV-negative control group was significantly different (30 and 2%, respectively). The highest rate of seroprevalence in HIV-infected patients was detected at the age of 40-49 (42%) and the lowest rate at the age of 20-29 years (16.6%). In comparison with formerly conducted studies, our data clearly showed an increase in the HHV8 seroprevalence in HIV-infected patients, both in men and women. Therefore, we conclude that the low rate of clinical KS is associated with an improved immunological status due to an optimized anti-HIV therapy.

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Section: Discussionmentioning

confidence: 99%

Do fewer cases of Kaposi’s sarcoma in HIV-infected patients reflect a decrease in HHV8 seroprevalence?

Reinheimer

Allwinn

Stürmer

2011

Med Microbiol Immunol

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“…However, in patients with extensive mucocutaneous disease or visceral organ involvement, combined HAART and systemic chemotherapy is indicated. Pegylated Liposomal doxorubicin and paclitaxel are the chemotherapeutic agents of choice [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, another promising therapeutic strategy for KS is the inhibition of matrix metalloproteinases (MMPs). MMPs are endopeptidases that assist in angiogenesis via degradation of extracellular matrix [23]. The ability to molecularly target intricate pathways in cancer has been transformed from a hopeful idea to a definitive reality.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Kaposi’s Sarcoma Causing Gastrointestinal Bleeding: Report of an Unusual Case

Huang¹

2017

Austin J Gastroenterol

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Kaposi's sarcoma is a vascular tumor associated with human herpesvirus 8 (HHV8) infections that most commonly involve the skin. Kaposi's sarcoma with the gastrointestinal tract is not rare in acquired immunodeficiency syndrome and can also occur in immunosuppressed patients. These patients may present with vague and variable clinical manifestations. Herein, we report a case of a 70-year-old man with Sjogren's syndrome and cutaneous Kaposi sarcoma who presented with gastrointestinal bleeding. On upper endoscopy, infiltrative, circumferential, reddish polypoid lesion involving the body and antrum of the stomach was seen. Histologic examination revealed spindle cell proliferation, and immunohistochemistry stains for human herpes virus-8 and CD34 were positive, supporting the diagnosis of metastatic Kaposi's sarcoma. Following this, we present an overview of literature on gastrointestinal Kaposi's sarcoma with emphasis on diagnosis and management.

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“…Therefore, staging of the tumour based on the clinical signs is recommended. Local treatments such as surgical excision or radiotherapy are mainly indicated for selected, small lesions, while systemic treatments include chemotherapy or biological therapy particularly with recombinant interferon-α due to its immunomodulating and anti-angiogenetic properties [10] . Systemic treatments are generally applied to disseminated and symptomatic forms.…”

Section: Discussionmentioning

confidence: 99%

Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient

Zoubeidi

Aydi

Daoud

et al. 2016

European Journal of Case Reports in Internal Medicine

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Introduction Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negative patient presenting with lymphadenopathy who was found to have KS. Case Report A 67-year-old patient was admitted for exploration of polyadenopathies in the context of a general decline in health. Physical examination revealed an erythematosus left lower limb rash associated with angiomatous nodules and multiple lymphadenopathies. The diagnosis of erysipelas in the left leg was retained and the patient was treated with good evolution of the rash but persistence of the angiomatous nodules and the polyadenopathies. Skin and lymph node biopsies led to a diagnosis of KS. The patient is proposed for polychemotherapy. Conclusion KS must be suspected in lymphadenopathies despite the absence of typical cutaneous signs of the disease and in immunocompetent patients. LEARNING POINTS Involvement of the lymph nodes is extremely uncommon in the classical variant form of Kaposi’s sarcoma (KS). Human herpes virus-8 is an important cofactor in all forms of KS. Pathology and immunohistochemistry are key to diagnosing KS. KS must be suspected in lymphadenopathies without typical cutaneous signs of the disease and in immunocompetent patients.

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Targeted Therapy for Kaposi Sarcoma

Cited by 35 publications

References 60 publications

Do fewer cases of Kaposi’s sarcoma in HIV-infected patients reflect a decrease in HHV8 seroprevalence?

Do fewer cases of Kaposi’s sarcoma in HIV-infected patients reflect a decrease in HHV8 seroprevalence?

Metastatic Kaposi’s Sarcoma Causing Gastrointestinal Bleeding: Report of an Unusual Case

Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient

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