Targeted Therapy against Metastatic Melanoma Based on Self‐Assembled Metal‐Phenolic Nanocomplexes Comprised of Green Tea Catechin

Li, Ké; Xiao, Gao; Richardson, Joseph J.; Tardy, Blaise L.; Ejima, Hirotaka; Huang, Wen; Guo, Junling; Liao, Xuepin; Shi, Bi

doi:10.1002/advs.201801688

Cited by 123 publications

(94 citation statements)

References 47 publications

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“…For the challenging problem of targeted therapy of metastatic melanoma, the assembly of EGCG and metal shows good results. Using green tea polyphenols, EGCG, and lanthanide metal ions (Sm 3+ ) as building blocks, Li et al ( 2019a ) designed self-assembled Sm-III-EGCG nanocomplexes with synergistic antitumor properties. The systemic toxic effects of these nanocomposites on healthy cells are negligible, but the activity of melanoma cells is significantly reduced by effectively regulating their metabolic pathway.…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

“…The systemic toxic effects of these nanocomposites on healthy cells are negligible, but the activity of melanoma cells is significantly reduced by effectively regulating their metabolic pathway. Green tea–based self-assembled nanocomposites have all the key features of promising clinical candidates and can address the challenges associated with the treatment of advanced metastatic melanoma (Li et al, 2019a ).…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

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Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Zhang

Cheng

et al. 2020

Front. Chem.

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Polyphenol, characterized by various phenolic rings in the chemical structure and an abundance in nature, can be extracted from vegetables, grains, chocolates, fruits, tea, legumes, and seeds, among other sources. Tannic acid (TA), a classical polyphenol with a specific chemical structure, has been widely used in biomedicine because of its outstanding biocompatibility and antibacterial and antioxidant properties. TA has tunable interactions with various materials that are widely distributed in the body, such as proteins, polysaccharides, and glycoproteins, through multimodes including hydrogen bonding, hydrophobic interactions, and charge interactions, assisting TA as important building blocks in the supramolecular self-assembled materials. This review summarizes the recent immense progress in supramolecular self-assembled materials using TA as building blocks to generate different materials such as hydrogels, nanoparticles/microparticles, hollow capsules, and coating films, with enormous potential medical applications including drug delivery, tumor diagnosis and treatment, bone tissue engineering, biofunctional membrane material, and the treatment of certain diseases. Furthermore, we discuss the challenges and developmental prospects of supramolecular self-assembly nanomaterials based on TA.

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Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Zhang

Cheng

et al. 2020

Front. Chem.

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“…TheH RP-TA capsules showed comparable catalytic activity to free HRP, thus suggesting that the enzymatic activity was not significantly affected after assembly (Figure 5b and Figure S17). [23] Moreover,these capsules showed higher catalytic activity (ca. 25 %) than the HRP-TAc ore-shell particles,w hich is attributed to the likely improved mass transfer in the hollow (capsule) system.…”

Section: Forschungsartikelmentioning

confidence: 99%

Polyphenol‐Mediated Assembly of Proteins for Engineering Functional Materials

et al. 2020

Self Cite

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Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins. However, establishing general techniques for assembling proteins into nanomaterials is challenging owing to the complex physicochemical nature and potential denaturation of proteins. Here, a simple, versatile strategy is introduced to fabricate functional protein assemblies through the interfacial assembly of proteins and polyphenols (e.g., tannic acid) on various substrates (organic, inorganic, and biological). The dominant interactions (hydrogen‐bonding, hydrophobic, and ionic) between the proteins and tannic acid were elucidated; most proteins undergo multiple noncovalent stabilizing interactions with polyphenols, which can be used to engineer responsiveness into the assemblies. The proteins retain their structure and function within the assemblies, thereby enabling their use in various applications (e.g., catalysis, fluorescence imaging, and cell targeting).

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“…In a mouse melanoma tumor model, Sm III –EGCG nanocomplexes are directly compared with a clinical anticancer drug, 5-fluorouracil, and shows remarkable therapeutic effects on primary melanoma tumors and inhibition of metastasis of melanoma from invading other organs through targeted therapeutic effects [86]. Moreover, these results suggested that Sm III –EGCG complexes exhibited significantly lower adverse side effects than 5-fluorouracil when the anticancer therapy was performed on melanoma primary tumors.…”

Section: Phytochemicals Conjugated With Nps As Nanomedicinementioning

confidence: 99%

Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications

Wei

Chen

et al. 2019

Molecules

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Cancer is one of the foremost causes of death globally and also the major stumbling block of increasing life expectancy. Although the primary treatment of surgical resection, chemotherapy, and radiotherapy have greatly reduced the mortality of cancer, the survival rate is still low because of the metastasis of tumor, a range of adverse drug reactions, and drug resistance. For all this, it is relevant to mention that a growing amount of research has shown the anticarcinogenic effect of phytochemicals which can modulate the molecular pathways and cellular events include apoptosis, cell proliferation, migration, and invasion. However, their pharmacological potential is hindered by their low water solubility, low stability, poor absorption, and rapid metabolism. In this scenario, the development of nanotechnology has created novel formulations to maximize the potential use of phytochemicals in anticancer treatment. Nanocarriers can enhance the solubility and stability of phytochemicals, prolong their half-life in blood and even achieve site-targeting delivery. This review summarizes the advances in utilizing nanoparticles in cancer therapy. In particular, we introduce several applications of nanoparticles combined with apigenin, resveratrol, curcumin, epigallocatechin-3-gallate, 6-gingerol, and quercetin in cancer treatment.

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Targeted Therapy against Metastatic Melanoma Based on Self‐Assembled Metal‐Phenolic Nanocomplexes Comprised of Green Tea Catechin

Cited by 123 publications

References 47 publications

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Polyphenol‐Mediated Assembly of Proteins for Engineering Functional Materials

Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications

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