Targeted SPION siderophore conjugate loaded with doxorubicin as a theranostic agent for imaging and treatment of colon carcinoma

Nosrati, Rahim; Abnous, Khalil; Alibolandi, Mona; Mosafer, Jafar; Dehghani, Sadegh; Taghdisi, Seyed Mohammad; Ramezani, Mohammad

doi:10.1038/s41598-021-92391-w

Cited by 26 publications

(16 citation statements)

References 66 publications

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“…The investigators showed that the PVD-SPION-MUC1 Apt complex was successfully taken up by cancer cells, and conferred tumor inhibitory growth effects and improved survival in mice bearing C26 colon carcinoma (221). This complex also served as a diagnostic agent that improved contrast at the tumor site in magnetic resonance images (221). This study is one of the first to show the potential of siderophores as chemotherapy delivery agents and diagnostic tools in cancer.…”

Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 80%

“…A recent study conjugated the siderophore PVD from P. aeruginosa, a mixed-type siderophore with hydroxamate and catecholate groups, to synthesize superparamagnetic iron oxide nanoparticles (SPION) (221). The PVD-iron complex has strong binding and high stability, which protects it from hydrolysis and enzymatic degradation.…”

Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 99%

“…MUC1 Apt is one of the most studied aptamers as it specifically recognizes the mucin 1 (MUC1) protein that is strongly upregulated in most cancer cell surfaces, which makes it a great target in cancer (222). The investigators showed that the PVD-SPION-MUC1 Apt complex was successfully taken up by cancer cells, and conferred tumor inhibitory growth effects and improved survival in mice bearing C26 colon carcinoma (221). This complex also served as a diagnostic agent that improved contrast at the tumor site in magnetic resonance images (221).…”

Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 99%

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Understanding the Potential and Risk of Bacterial Siderophores in Cancer

et al. 2022

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Siderophores are iron chelating molecules produced by nearly all organisms, most notably by bacteria, to efficiently sequester the limited iron that is available in the environment. Siderophores are an essential component of mammalian iron homeostasis and the ongoing interspecies competition for iron. Bacteria produce a broad repertoire of siderophores with a canonical role in iron chelation and the capacity to perform versatile functions such as interacting with other microbes and the host immune system. Siderophores are a vast area of untapped potential in the field of cancer research because cancer cells demand increased iron concentrations to sustain rapid proliferation. Studies investigating siderophores as therapeutics in cancer generally focused on the role of a few siderophores as iron chelators; however, these studies are limited and some show conflicting results. Moreover, siderophores are biologically conserved, structurally diverse molecules that perform additional functions related to iron chelation. Siderophores also have a role in inflammation due to their iron acquisition and chelation properties. These diverse functions may contribute to both risks and benefits as therapeutic agents in cancer. The potential of siderophore-mediated iron and bacterial modulation to be used in the treatment of cancer warrants further investigation. This review discusses the wide range of bacterial siderophore functions and their utilization in cancer treatment to further expand their functional relevance in cancer detection and treatment.

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Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 80%

Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 99%

Section: Siderophores As Mediators Of Drug Deliverymentioning

confidence: 99%

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Understanding the Potential and Risk of Bacterial Siderophores in Cancer

et al. 2022

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“…Recently, theranostic agents, including MRI contrast agents, have been developed for the purpose of diagnosis and therapy at the same time [37]. For example, a tumor specific magnetic nanoparticle-loaded doxorubicin agent has been developed by various research groups in the imaging and treatment of cancer [38,39].…”

Section: Discussionmentioning

confidence: 99%

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Kantapan

Anukul

Leetrakool

et al. 2021

IJMS

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Cell-based therapy is a highly promising treatment paradigm in ischemic disease due to its ability to repair tissue when implanted into a damaged site. These therapeutic effects involve a strong paracrine component resulting from the high levels of bioactive molecules secreted in response to the local microenvironment. Therefore, the secreted therapeutic can be modulated by preconditioning the cells during in vitro culturing. Herein, we investigated the potential use of magnetic resonance imaging (MRI) probes, the “iron–quercetin complex” or IronQ, for preconditioning peripheral blood mononuclear cells (PBMCs) to expand proangiogenic cells and enhance their secreted therapeutic factors. PBMCs obtained from healthy donor blood were cultured in the presence of the iron–quercetin complex. Differentiated preconditioning PBMCs were characterized by immunostaining. An enzyme-linked immunosorbent assay was carried out to describe the secreted cytokines. In vitro migration and tubular formation using human umbilical vein endothelial cells (HUVECs) were completed to investigate the proangiogenic efficacy. IronQ significantly increased mononuclear progenitor cell proliferation and differentiation into spindle-shape-like cells, expressing both hematopoietic and stromal cell markers. The expansion increased the number of colony-forming units (CFU-Hill). The conditioned medium obtained from IronQ-treated PBMCs contained high levels of interleukin 8 (IL-8), IL-10, urokinase-type-plasminogen-activator (uPA), matrix metalloproteinases-9 (MMP-9), and tumor necrosis factor-alpha (TNF-α), as well as augmented migration and capillary network formation of HUVECs and fibroblast cells, in vitro. Our study demonstrated that the IronQ-preconditioning PBMC protocol could enhance the angiogenic and reparative potential of non-mobilized PBMCs. This protocol might be used as an adjunctive strategy to improve the efficacy of cell therapy when using PBMCs for ischemic diseases and chronic wounds. However, in vivo assessment is required for further validation.

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“…Nosrati et al . used AS1411 targeted SPIONs and loaded the aptamer with DOX for MRI and therapy of colon carcinoma 172 . While in vivo MRI in C26 xenografts could not clearly separate AS1411 and scrambled ssDNA conjugated SPIONs, the targeted formulation showed a significantly better tumor growth inhibition.…”

Section: Aptamers For Theranostic Applicationsmentioning

confidence: 99%

Aptamers used for molecular imaging and theranostics - recent developments

Bohrmann¹,

Burghardt²,

Haynes³

et al. 2022

Theranostics

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Aptamers are single stranded oligonucleotides that fold into three dimensional structures and are able to recognize a variety of molecular targets. Due to the similarity to antibodies with regards to specificity and affinity and their chemical versatility, aptamers are increasingly used to create targeted probes for in vivo molecular imaging and therapy. Hence, aptamer-based probes have been utilized in practically all major imaging modalities such as nuclear imaging, magnetic resonance imaging, x-ray computed tomography, echography and fluorescence imaging, as well as newer modalities such as surface enhanced Raman spectroscopy. Aside from targeting, aptamers have been used for the creation of sensors that allow the localized detection of cellular markers such as ATP in vivo . This review focuses on in vivo studies of aptamer-based probes for imaging and theranostics since the comprehensive overview by Bouvier-Müller and Ducongé in 2018.

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Targeted SPION siderophore conjugate loaded with doxorubicin as a theranostic agent for imaging and treatment of colon carcinoma

Cited by 26 publications

References 66 publications

Understanding the Potential and Risk of Bacterial Siderophores in Cancer

Understanding the Potential and Risk of Bacterial Siderophores in Cancer

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Aptamers used for molecular imaging and theranostics - recent developments

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