Targeted Screening For Prostate Cancer In High Risk Families: Early Onset Is A Significant Risk Factor For Disease In First Degree Relatives

Valéri, Antoine; Cormier, Laurent; Moineau, Marie-Pierre; Cancel‐Tassin, Géraldine; Azzouzi, R.; Doucet, Laurent; Baschet, F.; Cussenot, Isabelle; L'her, Joel; Berthon, Philippe; Mangin, P.; Cussenot, Olivier; Morin, Jean‐François; Fournier, Georges

doi:10.1016/s0022-5347(05)64663-0

Cited by 35 publications

(19 citation statements)

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“…Valeri et al reported that the proportion of relatives with PSA greater than 4 ng/ml and PCa detection was not significantly different according to familial status (sporadic or nonsporadic) [20]. However, our results differed.…”

Section: Discussioncontrasting

confidence: 83%

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

et al. 2011

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PurposeThere are few data regarding the epidemiology of hereditary or familial prostate cancer (PCa) in East Asians, especially in Korean men. Therefore, we evaluated the incidence of familial and hereditary PCa and the relation between socioeconomic status and the incidence of nonsporadic prostate cancer (NSPC).Materials and MethodsWe collected data from all patients who were treated for PCa at our center between November 2009 and January 2010. All patients were either newly diagnosed or had been diagnosed with PCa and seen as outpatients during the study period.ResultsIn a sample of 218 patients with PCa; 25 (11.5%) were NSPC patients, and 193 (88.6%) were sporadic PCa sporadic prostate cancer (SPC) patients. Overall, 11.5% of the patients had a positive family history. There was one hereditary PCa family (three patients, 1.4%) and 11 familial PCa families (22 patients, 10.1%). Patients were divided into three different age groups. Of these, 18 (9.3%) SPC patients and 6 (24%) NSPC patients were diagnosed with the disease at the age of 55 years or younger (p=0.02). Prostate-specific antigen (PSA) levels in the NSPC group were significantly higher than in the SPC group (7.2±3.2 versus 6.3±4.9 ng/ml, p=0.042). SPC patients had larger waist circumferences than did NSPC patients (p=0.041). There were no significant differences between the SPC and NSPC groups in terms of socioeconomic status, Gleason score, pathological stage, or pathologic Gleason grade.ConclusionsEast Asian NSPC patients are diagnosed at earlier ages than are SPC patients, even though the incidence of NSPC in the East Asian population is lower than in Western men.

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Section: Discussioncontrasting

confidence: 83%

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

et al. 2011

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“…Leur connaissance par une approche génétique est le fondement de nouvelles stratifications des candidats au dépistage du cancer de la prostate [34] et de nouvelles approches chimiopréventives [35]. ◊ SUMMARY Genetic susceptibility to prostate cancer Prostate cancer is the most frequent malignant tumor among men over 50 years old.…”

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Facteurs de risque génétiques pour le cancer de la prostate

Cussenot

Cancel‐Tassin

2004

Med Sci (Paris)

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“…Regardless of uncertainties associated with general population PSA screening, targeted PSA screening of men at high-risk due to family history of prostate cancer may be of benefit (Catalona et al, 2002;Valeri et al, 2002). Familial risk could account for up to 10% of cases, the proportion being much higher at young ages: 43% in men aged 55 or less (Carter et al, 1993).…”

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Feasibility of familial PSA screening: psychosocial issues and screening adherence

et al. 2006

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This study examined factors that predict psychological morbidity and screening adherence in first-degree relatives (FDRs) taking part in a familial PSA screening study. Prostate cancer patients (index cases -ICs) who gave consent for their FDRs to be contacted for a familial PSA screening study to contact their FDRs were also asked permission to invite these FDRs into a linked psychosocial study. Participants were assessed on measures of psychological morbidity (including the General Health Questionnaire; Cancer Worry Scale; Health Anxiety Questionnaire; Impact of Events Scale); and perceived benefits and barriers, knowledge; perceived risk/ susceptibility; family history; and socio-demographics. Of 255 ICs, 155 (61%) consented to their FDRs being contacted. Of 207 FDRs approached, 128 (62%) consented and completed questionnaires. Multivariate logistic regression revealed that health anxiety, perceived risk and subjective stress predicted higher cancer worry (P ¼ 0.05). Measures of psychological morbidity did not predict screening adherence. Only past screening behaviour reliably predicted adherence to familial screening (P ¼ 0.05). First-degree relatives entering the linked familial PSA screening programme do not, in general, have high levels of psychological morbidity. However, a small number of men exhibited psychological distress.

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Targeted Screening For Prostate Cancer In High Risk Families: Early Onset Is A Significant Risk Factor For Disease In First Degree Relatives

Abstract: Our results emphasize the usefulness of PSA screening in high risk families, including those without obvious hereditary features. Furthermore, early onset prostate cancer is a significant risk factor for prostate cancer in first degree relatives.

Cited by 35 publications

References 14 publications

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

Facteurs de risque génétiques pour le cancer de la prostate

Feasibility of familial PSA screening: psychosocial issues and screening adherence

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