Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1

Rezai-Zadeh, Natalie; Zhang, Xiaohong; Namour, Farès; Fejér, György; Wen, Yu‐Der; Yao, Yali; Győry, Ildikó; Wright, Kenneth L.; Seto, Edward

doi:10.1101/gad.1068003

Cited by 161 publications

(133 citation statements)

References 45 publications

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“…Alternatively, xPRMT1b may methylate specific transcriptional activators, bound to the Zic3 promoter, which in turn triggers Zic3 expression at the onset of neural induction. The transcription factor YY1 has recently been shown to recruit PRMT1 to an YY1-activated promoter (34). Several YY1 consensus sequences are present in the Xenopus Zic3 promoter, one of which is conserved in human (35).…”

Section: Discussionmentioning

confidence: 99%

The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

Batut

Vandel

Leclerc

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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We have previously shown that an increase in intracellular Ca 2؉ is both necessary and sufficient to commit ectoderm to a neural fate in Xenopus embryos. However, the relationship between this Ca 2؉ increase and the expression of early neural genes has yet to be defined. Using a subtractive cDNA library between untreated and caffeine-treated animal caps, i.e., control ectoderm and ectoderm induced toward a neural fate by a release of Ca 2؉ , we have isolated the arginine N-methyltransferase, xPRMT1b, a Ca 2؉ -induced target gene, which plays a pivotal role in this process. First, we show in embryo and in animal cap that xPRMT1b expression is Ca 2؉ -regulated. Second, overexpression of xPRMT1b induces the expression of early neural genes such as Zic3. Finally, in the whole embryo, antisense approach with morpholino oligonucleotide against xPRMT1b impairs neural development and in animal caps blocks the expression of neural markers induced by a release of internal Ca 2؉ . Our results implicate an instructive role of an enzyme, an arginine methyltransferase protein, in the embryonic choice of determination between epidermal and neural fate. The results presented provide insights by which a Ca 2؉ increase induces neural fate.calcium ͉ neural induction ͉ protein methyltransferase ͉ Xenopus

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Section: Discussionmentioning

confidence: 99%

The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

Batut

Vandel

Leclerc

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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“…Exonuclease activity of MRE11 is abrogated by substitution of an arginine residue regularly methylated by PRMT1 [9]. Furthermore, certain transcription factors or their co-activators can be arginine-methylated by PRMTs, affecting their transcriptional activity [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Methylation of Smad6 by protein arginine N‐methyltransferase 1

et al. 2006

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Signal transduction pathways utilize posttranslational modifications to regulate the activity of their components in a temporal-spatial and efficient fashion. Arginine methylation is one of the posttranslational modifications that can result in monomethylated-, asymmetric dimethylated-and/or symmetric dimethylated-arginine residues in proteins. Here we demonstrate that inhibitory-Smads (Smad6 and Smad7), but not receptorregulated-(R-)Smads and the common-partner Smad4, can be methylated by protein arginine N-methyltransferase (PRMT)1. Using mass-spectrometric analysis, we found that PRMT1 dimethylates arginine 74 (Arg 74 ) in mouse Smad6. PRMT1 interacts with the N-terminal domain of Smad6 in which Arg 74 residue is located. Assays examined so far have shown no significant differences between the functions of Smad6 and those of methylation-defective Smad6 (Smad6R74A). Both wild-type and Smad6R74A were equally efficient in blocking BMP-induced growth arrest upon their ectopic expression in HS-72 mouse Bcell hybridoma cells.

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“…Transcription factors, for example, recruit histone modifiers to gene promoters, thereby regulating gene expression (Morse 2003;Rezai-Zadeh et al 2003). In addition, modifiers are recruited by the general transcription machinery to modify histones along gene bodies as transcription progresses (Rodríguez-Navarro 2009).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Chromatin dynamics during DNA replication

2016

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Chromatin is composed of DNA and histones, which provide a unified platform for regulating DNA-related processes, mostly through their post-translational modification. During DNA replication, histone arrangement is perturbed, first to allow progression of DNA polymerase and then during repackaging of the replicated DNA. To study how DNA replication influences the pattern of histone modification, we followed the cell-cycle dynamics of 10 histone marks in budding yeast. We find that histones deposited on newly replicated DNA are modified at different rates: While some marks appear immediately upon replication (e.g., H4K16ac, H3K4me1), others increase with transcription-dependent delays (e.g., H3K4me3, H3K36me3). Notably, H3K9ac was deposited as a wave preceding the replication fork by ∼5-6 kb. This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation. Our results assign complementary roles for DNA replication and gene expression in defining the pattern of histone modification.

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Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1

Cited by 161 publications

References 45 publications

The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

Methylation of Smad6 by protein arginine N‐methyltransferase 1

Chromatin dynamics during DNA replication

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Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1

Cited by 161 publications

References 45 publications

The Ca 2 +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

The Ca 2 +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

Methylation of Smad6 by protein arginine N‐methyltransferase 1

Chromatin dynamics during DNA replication

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The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo

The Ca ² +-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo