Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions
Rajamanikkam Kamaraj,
Subhrojyoti Ghosh,
Souvadra Das
et al.
Abstract:Targeted protein
degradation or TPD, is rapidly emerging as a treatment
that utilizes small molecules to degrade proteins that cause diseases.
TPD allows for the selective removal of disease-causing proteins,
including proteasome-mediated degradation, lysosome-mediated degradation,
and autophagy-mediated degradation. This approach has shown great
promise in preclinical studies and is now being translated to treat
numerous diseases, including neurodegenerative diseases, infectious
diseases, and cancer. This rev… Show more
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