Targeted polymer-drug conjugates: Current progress and future perspective

Xu, Hongyan; Ma, Haifeng; Yang, Peimin; Zhang, Xia; Wu, Xiangxia; Yin, Wen; Wang, Hui; Xu, Dongmei

doi:10.1016/j.colsurfb.2015.10.001

Cited by 39 publications

(23 citation statements)

References 63 publications

(57 reference statements)

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“…The targeting moieties usually include monoclonal antibodies, peptides, folate acid, sugars, and so on. 5 However, in general case, targeting polymer prodrugs are prepared going through a series of synthetic steps complicatedly. Moreover, the targeting ability might be affected by various factors in vivo , for instance, serum proteins 6 and tumor types.…”

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confidence: 99%

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Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

et al. 2016

Mol. Pharmaceutics

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Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran–doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.

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confidence: 99%

“…Moreover, the targeting ability might be affected by various factors in vivo , for instance, serum proteins 6 and tumor types. 5 In addition to this, some polymers themselves can also recognize and accumulate in targeting sites specifically. For example, the conjugates modified by Dex can be located in liver in amounts of studies of its kind.…”

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confidence: 99%

Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

et al. 2016

Mol. Pharmaceutics

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“…The copolymer forms stable dispersible micelles, which can encapsulate DOX and release this drug at low pH, as a consequence of the disassembly of A : U pairs and protonation of tertiary amines, which led to the concomitant disaggregation of the micelles. Furthermore, the presence of folic acid (FA) at one termini of the hydrophobic segment confers targeting capability to the micelles due to the fact that the folate receptor is overexpressed in several human cancers …”

Section: Base‐pairing Interactions In Nucleobase‐functionalized Polymersmentioning

confidence: 99%

Functional Systems Derived from Nucleobase Self‐assembly

Prado

González‐Rodríguez

2020

ChemistryOpen

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Dynamic and reversible non‐covalent interactions endow synthetic systems and materials with smart adaptive functions that allow them to response to diverse stimuli, interact with external agents, or repair structural defects. Inspired by the outstanding performance and selectivity of DNA in living systems, scientists are increasingly employing Watson−Crick nucleobase pairing to control the structure and properties of self‐assembled materials. Two sets of complementary purine‐pyrimidine pairs (guanine:cytosine and adenine:thymine(uracil)) are available that provide selective and directional H‐bonding interactions, present multiple metal‐coordination sites, and exhibit rich redox chemistry. In this review, we highlight several recent examples that profit from these features and employ nucleobase interactions in functional systems and materials, covering the fields of energy/electron transfer, charge transport, adaptive nanoparticles, porous materials, macromolecule self‐assembly, or polymeric materials with adhesive or self‐healing ability.

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“…Such conjugation may maintain the fundamental properties of chitosan, enhance its solubility, and endow it with new properties ascribed to small active molecules [25,26]. In fact, polymer-drug conjugates have long been proven to be an effective form for improving the therapeutic effect and biological effect of a given drug [27][28][29], mainly in the following: (a).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Qin

2020

IJMS

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As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.

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Targeted polymer-drug conjugates: Current progress and future perspective

Cited by 39 publications

References 63 publications

Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

Functional Systems Derived from Nucleobase Self‐assembly

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

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