Targeted Photodynamic Therapy (PDT) of Lung Cancer with Biotinylated Silicon (IV) Phthalocyanine

Dong, Wenyi; Li, Ké; Wang, Shijie; Qiu, Ling; Liu, Qingzhu; Xie, Minhao; Lin, Jianguo

doi:10.2174/1389201021666200510001627

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…A large number of porphyrin-based photosensitizers (PS) has been investigated inclinic for the treatment of lung cancer by PDT [16][17][18][19][20][21][22], and the initial response has been encouraging. However, some of the first-generation PSs showed limited tumor specificity and prolonged skin phototoxicity.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy in Combination with Doxorubicin Is Superior to Monotherapy for the Treatment of Lung Cancer

et al. 2022

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We have previously shown that a radioactive (123I)-analog of methyl 3-(1′-(iodobexyloxy) ethyl-3-devinylpyropheophorbide-a (PET-ONCO), derived from chlorophyll-a can be used for positron emission tomography (PET) imaging of a variety of tumors, including those where 18F-FDG shows limitations. In this study, the photodynamic therapy (PDT) efficacy of the corresponding non-radioactive photosensitizer (PS) was investigated in a variety of tumor types (NSCLC, SCC, adenocarcinoma) derived from lung cancer patients in mice tumor models. The in vitro and in vivo efficacy was also investigated in combination with doxorubicin, and a significantly enhanced long-term tumor response was observed. The toxicity and toxicokinetic profile of the iodinated PS was also evaluated in male and female Sprague-Dawley rats and Beagle dog at variable doses (single intravenous injections) to assess reversibility or latency of any effects over a 28-day dose free period. The no-observed-adverse-effect (NOAEL) of the PS was considered to be 6.5 mg/kg for male and female rats, and for dogs, 3.45 mg/kg, the highest dose levels evaluated, respectively. The corresponding plasma Cmax and AYClast for male and female rats were 214,000 and 229,000 ng/mL and 3,680,000 and 3,810,000 h * ng/mL, respectively. For male and female dogs, the corresponding plasma Cmax and AYClast were 76,000 and 92,400 ng/mL and 976,000 and 1,200,000 h * ng/mL, respectively.

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Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy in Combination with Doxorubicin Is Superior to Monotherapy for the Treatment of Lung Cancer

et al. 2022

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“…Almost all organic and inorganic compounds are dissolved in dimethylsulfoxide (DMSO) and ethanol but especially the high doses of DMSO itself can trigger toxicity in the cells. Therefore solubility is preferred in safety drug applications and many methodologies are used to enhance the solubility of the compounds [19,[24][25][26][27][28] and the SiPc molecule examined in this study was highly soluble therefore it can be considered as solvent-safe for the cells. But these results should be extended for detailed investigation using mice models and other molecular techniques.…”

Section: Resultsmentioning

confidence: 99%

The effect of silicon phthalocyanine on cell death and mitochondrial membrane potential in pancreatic cancer cells

KAYA

BOGUSLU

KABAK

et al. 2022

Turkish Journal of Analytical Chemistry

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Silicon (SiPcs) phthalocyanines are advantageous because they do not aggregate due to their special structural features. Therefore, they have been widely used in a range of areas in chemical and biological technology. One of the common applications is the use of phthalocyanines on cancer therapies. Pancreas cancer is one of the most common cancers with a high rate of mortality around the world. In this study we therefore aimed to investigate the potential of SiPcs molecules which we previously synthesized for the first time, on increased cell death and the effect on mitochondrial activity in pancreatic cancer cells. The results showed the significantly selective cytotoxic effect of SiPc on cancer cells compared to normal cells. Mitochondrial membrane potential was not different in cancer cells but in normal cells after SiPcs treatment. Pre-incubation time (24h) of SiPcs before light irradiation induced more significant cytotoxicity in pancreatic cancer cells but not in normal cells compared to prolonged pre-incubation (48). This study revisited the biological function of previously synthesized SiPcs, and the results conclude the cytotoxic activity of SiPcs on pancreas cancer. These preliminary findings can be extended for other cancer types and detailed with in vivo models in the future.

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“…75 76 77 78 79 There has also been research into coupling photosensitizers with compounds that might specifically target tumor cells in the lung, although data are exclusively preclinical at this time. 80…”

Section: Bronchoscopic Interventions For Malignant Central Airway Obs...mentioning

confidence: 99%

Malignant Central Airway Obstruction: What's New?

Shaller

Filsoof

Pineda

et al. 2022

Semin Respir Crit Care Med

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Malignant central airway obstruction (MCAO) is a debilitating and life-limiting complication that occurs in an unfortunately large number of individuals with advanced intrathoracic cancer. Although the management of MCAO is multimodal and interdisciplinary, the task of providing patients with prompt palliation falls increasingly on the shoulders of interventional pulmonologists. While a variety of tools and techniques are available for the management of malignant obstructive lesions, advancements and evolution in this therapeutic venue have been somewhat sluggish and limited when compared with other branches of interventional pulmonary medicine (e.g., the early diagnosis of peripheral lung nodules). Indeed, one pragmatic, albeit somewhat uncharitable, reading of this article's title might suggest a wry smile and shug of the shoulders as to imply that relatively little has changed in recent years. That said, the spectrum of interventions for MCAO continues to expand, even if at a less impressive clip. Herein, we present on MCAO and its endoscopic and nonendoscopic management-that which is old, that which is new, and that which is still on the horizon.

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Targeted Photodynamic Therapy (PDT) of Lung Cancer with Biotinylated Silicon (IV) Phthalocyanine

Cited by 12 publications

References 38 publications

Photodynamic Therapy in Combination with Doxorubicin Is Superior to Monotherapy for the Treatment of Lung Cancer

Photodynamic Therapy in Combination with Doxorubicin Is Superior to Monotherapy for the Treatment of Lung Cancer

The effect of silicon phthalocyanine on cell death and mitochondrial membrane potential in pancreatic cancer cells

Malignant Central Airway Obstruction: What's New?

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