Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

Abstract

The application of intelligent responsive nanoparticles in combination therapy has become an emerging issue for cancer therapeutics. In this work, we have constructed a targeted nanoparticle that is capable of...

Self-assembly behavior and sustained drug release properties of amphiphilic poly(amino acid)s

“…1 H-NMR analysis. 1 HNMR analysis was performed to describe the positions of various hydrogen atoms on the main or side chains. Meanwhile, its integrated area could also represent the number of ''H''.…”

“…Chemotherapy is one of the most commonly used and effective strategies in cancer treatment. 1 However, most of the chemotherapeutic drugs used in clinical practice are cytotoxic, which have disadvantages such as low solubility, poor stability and poor pharmacokinetic properties. 2 It is extremely important and significant to establish a drug delivery system that can target the tumor site.…”

A pH/ROS dual-responsive nanoparticle system for tumor targeting combined chemotherapy/phototherapy

“…The PDT ability of DI@UiO-TPF3 can be evaluated by the production of 1 O 2 using the reactive oxygen species probe 1,3-diphenylisobenzofuran (DPBF) and nanoparticles under 808 nm near-infrared light irradiation. 32 DI@UiO-TPF3 (100 mg mL −1 ) and DPBF (3 μg mL −1 ) were dispersed in DMSO solution. The same concentration of free ICG (10 μg mL −1 ) solution was used as the control group, and it was irradiated with 808 nm NIR for 0, 1, 2, 3, 4, 5 and 6 min, and the absorbance measured at 410 nm using an UV-vis spectrophotometer was used to analyze the production of 1 O 2 .…”

A pH/GSH Dual‐Responsive, Folic Acid Targeted Drug Delivery System Based on Bovine Serum Albumin Nanoparticles for Cancer Therapy

“…[4] In consequence, multimodal combination therapy is considered a promising way for tumor treatment. [5,6] For example, chemotherapy combined with photodynamic therapy DOI: 10.1002/ppsc.202300184 (PDT), [7] chemodynamic therapy (CDT), [8] PDT/PTT, [9] or PDT/CDT [10] and other multimodal combination therapies have significantly improved the efficacy of anti-tumor according to their low toxicity and side effects. However, the efficacy of multimodal combination therapy for cancer treatment is often weakened by features of the tumor microenvironment (TME) including insufficient oxygen concentration, [11] high concentrations of glutathione (GSH) [12] as well as hydrogen peroxide (H 2 O 2 ).…”