Targeted nanosystems: Advances in targeted dendrimers for cancer therapy

Yang, Hu

doi:10.1016/j.nano.2015.11.012

Cited by 65 publications

(41 citation statements)

References 48 publications

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“…It is generally agreed that more quantitative and systematic strategies are needed for optimizing in vivo efficacy parameters to increase probability for success in the clinic. In Section 2.3, we briefly review preclinical optimization strategies using dendrimer-based CNDP engineering, which is described more extensively elsewhere [204]. Similarly, Kaminskas et al [188] recently described an in silico model for predicting intravenous pharmacokinetics for dendrimers based on their physicochemical properties.…”

Section: Predictions For the Futurementioning

confidence: 99%

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

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Section: Predictions For the Futurementioning

confidence: 99%

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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“…They can also be used for diagnostic imaging of cancer cells (e.g., MRI). Gadolinium dendrimer conjugates were shown to enable selective large-scale targeting and imaging of tumours [45,171,172].…”

Section: Nanotechnological Approaches In Treating Skin Cancermentioning

confidence: 99%

Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology

Orthaber

Pristovnik

Skok

et al. 2017

Journal of Nanomaterials

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The life expectancy in the Western world is increasing for a long time, which is the courtesy of a higher life standard, a more thorough hygiene, and, of course, the progress of modern medicine. Nevertheless, one of the illnesses that still proves to be a great challenge regardless of the recent advancements in medicine is cancer. Skin cancer is, according to the World Health Organization, the most common malignancy for the white population. The beginning of the paper offers a brief overview of the latest available information concerning epidemiology, aetiology, diagnostics, and treatment options for skin cancer, whereas the rest of the article deals with modern approaches to skin cancer treatment, highlighting recent development of nanotechnology based treatment approaches. Among these, we focus especially on the newest nanotechnological approaches combined with chemotherapy, a field which specialises in target specificity, drug release control, and real time monitoring with the goal being to diminish unwanted side effects and their severity, achieving a cheaper treatment and a generally more efficient chemotherapy. The field of nanotechnology is a rapidly developing one, judging by already approved clinical studies or by new theranostic agents that combine both the therapeutic and diagnostic modalities.

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“…Nanomaterials designed for cancer therapy can be as diverse as micelles, dendrimers, inorganic NP, carbon NP and nanotubes, nanodiamonds, nanoemulsions, viral nanocarriers, peptide NP, solid lipid NP [15][16][17][18], etc., although most clinically available nanomaterials for human use are liposomes and polymer-based nanoformulations [11,12]. In fact, the first nanotechnology-based cancer drugs on the market was a pegylated liposome with the drug doxorubicin encapsulated (Doxil) [5], which was approved in 1995 by the Food and Drug Administration (FDA) for the treatment of AIDS-related…”

Section: Cancer Therapymentioning

confidence: 99%

Clinical advances of nanocarrier-based cancer therapy and diagnostics

Luque-Michel

Imbuluzqueta

Sebastián

et al. 2016

Expert Opinion on Drug Delivery

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Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitoring, evaluating and individualizing cancer treatments in real-time. Areas covered: Polymer-based nanocarriers have been extensively studied to maximize cancer treatment efficacy and minimize the adverse effects of standard therapeutics. Regarding diagnosis, nanomaterials like quantum dots, iron oxide nanoparticles or gold nanoparticles have been developed to provide rapid, sensitive detection of cancer and, therefore, facilitate early treatment and monitoring of the disease. Therefore, multifunctional nanosystems with both imaging and therapy functionalities bring us a step closer to delivering precision/personalized medicine in the cancer setting. Expert opinion: There are multiple barriers for these new nanosystems to enter the clinic, but it is expected that in the near future, nanocarriers, together with new 'targeted drugs', could replace our current treatments and cancer could become a nonfatal disease with good recovery rates. Joint efforts between scientists, clinicians, the pharmaceutical industry and legislative bodies are needed to bring to fruition the application of nanosystems in the clinical management of cancer.

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Targeted nanosystems: Advances in targeted dendrimers for cancer therapy

Cited by 65 publications

References 48 publications

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology

Clinical advances of nanocarrier-based cancer therapy and diagnostics

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