Targeted nanostructured lipid carriers for doxorubicin oral delivery

Moraes, Suellen Silveira; Marinho, Andreia; Lima, Sérgio; Granja, Andreia; Araújo, João P.; Sousa, C. T.; Nunes, Cláudia

doi:10.1016/j.ijpharm.2020.120029

Cited by 28 publications

(11 citation statements)

References 33 publications

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“…The resulting NLCs were found to be with particle size ranging between 20 and 50 nm, while EE was found to be ranging between 90 and 93%. The optimization studies revealed high drug loading, smaller particle size and good EE, ostensibly owing to the rational selection of the blend of lipid mixture which helped in designing the NLC formulation with desired formulation attributes ( Moraes et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma

Wang

Sun

Wen

et al. 2021

Saudi Pharmaceutical Journal

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The current study focuses on the development and evaluation of nano lipidic carriers (NLCs) for codelivery of sorafenib (SRF) and ganoderic acid (GA) therapy in order to treat hepatocellular carcinoma (HCC). The dual drug-loaded NLCs were prepared by hot microemulsion technique, where SRF and GA as the drugs, Precirol ATO5, Capmul PG8 as the lipids, while Solutol HS15 and ethanol was used as surfactant and cosolvents. The optimized drug-loaded NLCs were extensively characterized through in vitro and in vivo studies. The optimized formulation had particle size 29.28 nm, entrapment efficiency 93.1%, and loading capacity 14.21%. In vitro drug release studies revealed>64% of the drug was released in the first 6 h. The enzymatic stability analysis revealed stable nature of NLCs in various gastric pH, while accelerated stability analysis at 25 ◦ C/60% RH indicated the insignificant effect of studied condition on particle size, entrapment efficiency, and loading capacity of NLCs. The cytotoxicity performed on HepG2 cells indicated higher cytotoxicity of SRF and GA-loaded NLCs as compared to the free drugs (p < 0.05). Furthermore, the optimized formulation suppressed the development of hepatic nodules in the Wistar rats and significantly reduced the levels of hepatic enzymes and nonhepatic elements against DEN intoxication. The SRF and GA-loaded NLCs also showed a significant effect in suppressing the tumor growth and inflammatory cytokines in the experimental study. Further, histopathology study of rats treated SRF and GA-loaded NLCs and DEN showed absence of necrosis, apoptosis, and disorganized hepatic parenchyma, etc. over other treated groups of rats. Overall, the dual drug-loaded NLCs outperformed over the plain drugs in terms of chemoprotection, implying superior therapeutic action and most significantly eliminating the hepatic toxicity induced by DEN in Wistar rat model.

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Section: Resultsmentioning

confidence: 99%

Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma

Wang

Sun

Wen

et al. 2021

Saudi Pharmaceutical Journal

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“…Upon immobilizing the AuNTs@graphene composite on ITO slides, DOX was loaded onto graphene through physical adsorption, resulting in a blueshift of the LSPR composite and an increase in the local dielectric constant. [36][37][38][39] As the position of the LSPR peak is closely related to the dielectric constant, the increase in the local dielectric constant may cause a shift of the LSPR peak position towards the short wavelength, i.e., blueshift. Additionally, the adsorption of DOX molecules may also impact the surface charge density distribution of the composites, thereby affecting their LSPR peak positions.…”

Section: In Vitro Release Of Dox and Kinetic Modellingmentioning

confidence: 99%

“…2b). The DOX-loaded composites were released in various environments, and subsequently adjusted to facilitate release kinetic analysis, following the method of S. Moraes et al 37 The DOX release rate was 41.06% under neutral conditions at pH = 7.4 and gradually increased with decreasing pH, reaching 70.39% and 75.42% after two hours at pH = 5.5 and pH = 4.5, respectively, and its Langmuir adsorption isotherm equation is shown in Fig. 2c.…”

Section: In Vitro Release Of Dox and Kinetic Modellingmentioning

confidence: 99%

Plasmonic nanoprobes on single AuNTs for evaluating and monitoring the dynamic release of 2D drug carriers

Yu,

Wang,

Cai

et al. 2023

J. Mater. Chem. B

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“…Therefore, significant trust and scientific effort has been put into the nanotechnological approach to overcome all the hurdles associated with chemotherapy. Various types of nanocarriers have been prepared and loaded with Gels 2023, 9, 769 2 of 18 different chemotherapeutics, aiming to achieve improved antitumour efficacy, prolonged and sustained release, and to lessen the adverse events [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Voycheva,

Slavkova,

Popova

et al. 2023

Gels

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Hydrogels can offer many opportunities for drug delivery strategies. They can be used on their own, or their benefits can be further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes in the surrounding environment can be utilized as gatekeepers and provide sustained on-demand drug release. In this study, a hybrid nanosystem for temperature- and pH-sensitive delivery was prepared from MCM-41 nanoparticles grafted with a newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles were chemically modified by the attachment of carboxyl groups. Later, they were grafted with agar (AA) and vinylcaprolactam (VCL) by free radical polymerization. Doxorubicin was applied as a model hydrophilic chemotherapeutic drug. The successful formulation was confirmed by FT-IR and TGA. Transmission electron microscopy and dynamic light scattering analysis showed small particles with negative zeta potential. Their release behaviour was investigated in vitro in media with different pH and at different temperatures. Under tumour simulating conditions (40 °C and pH 4.0), doxorubicin was almost completely released within 72 h. The biocompatibility of the proposed nanoparticles was demonstrated by in vitro haemolysis assay. These results suggest the possible parenteral application of the newly prepared hydrogel-functionalized mesoporous silica nanoparticles for temperature-sensitive and pH-triggered drug delivery at the tumour site.

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Targeted nanostructured lipid carriers for doxorubicin oral delivery

Cited by 28 publications

References 33 publications

Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma

Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma

Plasmonic nanoprobes on single AuNTs for evaluating and monitoring the dynamic release of 2D drug carriers

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

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