Targeted nanoparticles for cancer therapy

Gu, Frank; Karnik, Rohit; Wang, Andrew Z.; Alexis, Frank; Levy‐Nissenbaum, Etgar; Hong, Seungpyo; Langer, Robert; Farokhzad, Omid C.

doi:10.1016/s1748-0132(07)70083-x

Cited by 503 publications

(397 citation statements)

References 124 publications

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“…As the use of microparticles for oral administration is documented and an attempt to enhance the bioavailability of poorly water-soluble drugs has been well thought of in order to increase the intestinal absorption of the drug [13][14][15]. Pectin is a natural, non-toxic, anionic, soluble and heterogeneous complex polysaccharide composed of linear a-D-galacturonic acid with 1,4-glycosidic linkages [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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Folic acid is used for preventing and treating multiple diseases and disorders, administered in the form of oral supplements. The present research work was aimed to study the influence of two non-ionic surfactants Poloxamer and Tween 80 (Polysorbate 80) on pectin submicrospheres formulations. Typical natural polymer pectin was used to encapsulate folic acid by cross linking method. The resultant submicrospheres contributed to improve the aqueous solubility to enhance the bioavailability of folic acid. During investigation, it was observed that pectin polymers influenced kinetics of the rate of reaction more intensively than the surfactants. The physical phenomenon caused the change in their size, shape and chemistry of pectin polymers transforming into submicrospheres in aqueous condition. The characteristic differences of submicrospheres were assessed by scanning electron microscopy, differential scanning calorimetry and Fouriertransform infrared spectroscopy. The average diameters of the submicrospheres ranged between 250 and 500 nm. The encapsulation efficiency of submicrospheres ranged between 80 and 96 %. The characteristic swelling behavior of lyophilized submicrospheres was influenced by the ratio of pectin polymers and folic acid used in the formulations. The submicrospheres systems exhibited controlled release of folic acid due to the pH-dependent solubility of pectin polymers in aqueous medium. The submicrospheres showed good haemocompatibility suggesting them to be promising candidates for oral delivery.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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“…[43] Despite the widespread utilization of wet-chemistry routes, they still suffer from some inherent properties to control the mentioned factors which results in uneven mixing and local temperature fluctuations. [44] For instance, although the coprecipitation method offers a good control over the shape and phase uniformity of nanoparticles, [45] maintaining and controlling the product homogeneity is problematic and needs multipurification steps for obtaining stable monodisperse nanoparticles. [46] However, pH, the ratio of salts and the nature of the base can be regulated for a better control over the reaction.…”

Section: Synthesis Of Mnpsmentioning

confidence: 99%

“…Peptides have numerous benefits due to their ease www.advancedsciencenews.com www.advhealthmat.de of conjugation, high activity per mass unit, high stability and low cost allowing for long-term storage. [44,556] In particular, the physicochemical properties of the nanoparticles decorated with peptides are not likely to be changed due to small sizes of peptides (much smaller than anitbodies). [557] Besides, simpler structures of peptide which is inherently originated from their shorter chains lead to more environmentally resistant molecules with improved stability.…”

Section: Peptidesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…In addition to in vitro cancer imaging, bioconjugated CdTe QDs can be potentially applied for some in vivo cancer studies [75][76][77]. To date, there are very limited studies available reporting the use of CdTe QDs for in vivo imaging.…”

Section: Cdte Quantum Dots For Targeted In Vitro and In Vivo Imagingmentioning

confidence: 99%

Aqueous phase synthesis of CdTe quantum dots for biophotonics

Yong

Law

Roy

et al. 2010

Journal of Biophotonics

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Over the past few years, CdTe quantum dots have been demonstrated as powerful probes for biophotonics applications. The aqueous phase synthesis technique remains the best approach to make high quality CdTe QDs in a single‐pot process. CdTe QDs prepared directly in the aqueous phase can have quantum yield as high as 80%. In addition, the surface of CdTe QDs prepared using the aqueous phase technique is functionalized with reactive groups that enable them to be directly conjugated with specific ligands for targeted delivery and sensing. In this contribution, we review recent progress in fabricating aqueous CdTe QDs and exploiting their optical properties in novel approaches to biomedical imaging and sensing applications. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Targeted nanoparticles for cancer therapy

Cited by 503 publications

References 124 publications

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Aqueous phase synthesis of CdTe quantum dots for biophotonics

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