Targeted Nano-Delivery of Flutamide with polymeric and lipid nanoparticles

Ghaemi, Amirhossein; Khanizadeh, Amirhossein; Pourmadadi, Mehrab; Yazdian, Fatemeh; Rashedi, Hamid; Rahdar, Abbas; Fathi-karkan, Sonia

doi:10.1016/j.eurpolymj.2024.113124

European Polymer Journal

2024

DOI: 10.1016/j.eurpolymj.2024.113124

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Targeted Nano-Delivery of Flutamide with polymeric and lipid nanoparticles

Amirhossein Ghaemi,

Amirhossein Khanizadeh,

Mehrab Pourmadadi

et al.

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2024

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Cited by 5 publications

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Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Safaran,

Javadi,

Pourmadadi

et al. 2024

J Nanopart Res

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This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. Zone of inhibition and viability studies provided insights into antibacterial efficacy. Some approaches incorporated stimuli-responsive polymers or targeting ligands to facilitate controlled or targeted drug release. Overall, the nanocarriers demonstrated potential for sustained antibiotic levels, reduced dosing, and improved treatment of biofilms and intracellular infections compared to free drug administration. The review offers a comprehensive analysis of this promising field with implications for combating antibiotic resistance.

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Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Safaran,

Javadi,

Pourmadadi

et al. 2024

J Nanopart Res

View full text Add to dashboard Cite

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Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Pourmadadi,

Dehaghi,

Ghaemi

et al. 2024

Inorganic Chemistry Communications

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Advancing cancer therapy: Unveiling the cutting-edge potential of carmustine nano carriers for targeted treatment

Khanizadeh,

Ghaemi,

Pourmadadi

et al. 2024

Journal of Drug Delivery Science and Technology

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Targeted Nano-Delivery of Flutamide with polymeric and lipid nanoparticles

Cited by 5 publications

References 87 publications

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Advancing cancer therapy: Unveiling the cutting-edge potential of carmustine nano carriers for targeted treatment

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