Targeted mutagenesis of specific genomic DNA sequences in animals for thein vivogeneration of variant libraries
Julia Falo-Sanjuan,
Yuliana Diaz-Tirado,
Meghan A. Turner
et al.
Abstract:Understanding how the number, placement and affinity of transcription factor binding sites dictates gene regulatory programs remains a major unsolved challenge in biology, particularly in the context of multicellular organisms. To uncover these rules, it is first necessary to find the binding sites within a regulatory region with high precision, and then to systematically modulate this binding site arrangement while simultaneously measuring the effect of this modulation on output gene expression. Massively par… Show more
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