Targeted modification of gut microbiota and related metabolites via dietary fiber

Nie, Qixing; Sun, Yonggan; Li, Mingzhi; Zuo, Sheng; Chen, Chunhua; Lin, Qiongni; Nie, Shaoping

doi:10.1016/j.carbpol.2023.120986

Cited by 20 publications

(6 citation statements)

References 35 publications

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“…Previous reports have suggested that Bacteroides is involved in many important metabolic activities in the colon, including carbohydrate fermentation, nitrogenous substance utilization, and biotransformation of bile acids and other steroids. Some species of Bacteroides can produce indole-3-lactic acid, indole-3-acetic acid, and tryptamine ( Liu Y. et al, 2023 ; Nie et al, 2023 ). Enterobacteriaceae have also been reported to have the ability to metabolize tryptophan in vivo ( Zhang J. et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota

Zou,

Ding,

et al. 2023

Front. Microbiol.

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Dysbiosis of gut microbiota and metabolic pathway disorders are closely related to the ulcerative colitis. Through network pharmacology, we found that puerarin is a potential ingredient that can improve the crypt deformation and inflammatory infiltration in mice, and decrease the levels of IL-1β, IL-6 and TNF-α significantly. Listeria, Alistipes and P. copri gradually became dominant bacteria in UC mice, which were positively correlated with inflammatory factors. Puerarin effectively improved dysbiosis by reducing the abundance of Alistipes, P. copri and Veillonella, and increasing the level of Desulfovibrionacea. Correlation network and metabolic function prediction analysis of the microbiota showed that they formed a tightly connected network and were widely involved in carbohydrate metabolism and amino acid metabolism. Specifically, we observed significant changes in the tryptophan metabolism pathway in DSS mice, with an increase in the abundance of Bacteroidetes and Enterobacteriaceae involved in tryptophan metabolism. However, this metabolic disorder was alleviated after puerarin treatment, including the reversal of 3-HAA levels and an increase in the abundance of Rhodobacteraceae and Halomonadaceae involved in kynurenine metabolism, as well as a significant increase in the purine metabolite guanosine. In conclusion, our study suggests that puerarin has a good therapeutic effect on UC, which is partially achieved by restoring the composition and abundance of gut microbiota and their metabolism.

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Section: Discussionmentioning

confidence: 99%

Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota

Zou,

Ding,

et al. 2023

Front. Microbiol.

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“…β-Glucan was reported to modulate the gut microbiota and stimulate the immune system. 69 By binding to receptors and macrophages on the cell surface, β-glucan may promote the production of cytokinin, and induce and activate the activity of T cells and HK cells. 70 Similar to β-glucan, arabinoxylan has been shown to affect different immune cells by augmenting a wide range of immune responses in vitro and in vivo, and regulate immune activity by enhancing the function of macrophages.…”

Section: Biological Activitiesmentioning

confidence: 99%

Section: Non-starch Polysaccharides In Barleymentioning

confidence: 99%

Structural characteristics and biological activities of polysaccharides from barley: a review

Yao,

Yin,

Nie

2024

Food Funct.

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“…A randomized controlled trial (NCT03275662) demonstrated that a high-fiber diet increased the activity of microbial-encoded glycan-degrading carbohydrate-activating enzymes (CAZymes), leading to a gradual enhancement of microbial diversity, reduced inflammatory markers, and modulation of the immune status (162). Additionally, Nie et al observed selective increases in the activity of Mycobacterium avium spp., Prevotella spp., and Spirochaetes militaris following consumption of different dietary fiber beverages, along with reductions in the abundance of Clostridium perfringens and Anaplasma fragilis (163). Changes in dietary patterns, such as increased consumption of high-fat and high-salt foods, have been implicated in altering the gut microbiota composition and function, thereby promoting chronic inflammation and tumorigenesis.…”

Section: Dietary Interventionmentioning

confidence: 99%

The role of the gut microbiota in tumor, immunity, and immunotherapy

Xie,

Liu

2024

Front. Immunol.

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In recent years, with the deepening understanding of the gut microbiota, it has been recognized to play a significant role in the development and progression of diseases. Particularly in gastrointestinal tumors, the gut microbiota influences tumor growth by dysbiosis, release of bacterial toxins, and modulation of host signaling pathways and immune status. Immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment efficacy by enhancing immune cell responses. Current clinical and preclinical studies have demonstrated that the gut microbiota and its metabolites can enhance the effectiveness of immunotherapy. Furthermore, certain gut microbiota can serve as biomarkers for predicting immunotherapy responses. Interventions targeting the gut microbiota for the treatment of gastrointestinal diseases, especially colorectal cancer (CRC), include fecal microbiota transplantation, probiotics, prebiotics, engineered bacteria, and dietary interventions. These approaches not only improve the efficacy of ICIs but also hold promise for enhancing immunotherapy outcomes. In this review, we primarily discuss the role of the gut microbiota and its metabolites in tumors, host immunity, and immunotherapy.

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Targeted modification of gut microbiota and related metabolites via dietary fiber

Cited by 20 publications

References 35 publications

Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota

Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota

Structural characteristics and biological activities of polysaccharides from barley: a review

The role of the gut microbiota in tumor, immunity, and immunotherapy

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