Targeted metabolomics unravels altered phenylalanine levels in piglets receiving total parenteral nutrition

Jiang, Lu; Liu, Yang; Zhou, Yongchang; Xu, Qing-Yang; Cheng, Siyang; Yan, Junkai; Xiao, Yongtao; Han, Lianshu; Wang, Ying; Cai, Wei

doi:10.1096/fj.202300261rr

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…After L. johnsonii treatment, liver steatosis was attenuated as a result of decreased fatty acid synthesis and increased fatty acid oxidation. We previously showed that the expression of hepatic Cpt1α, an enzyme involved in fatty acid oxidation, was significantly suppressed in both piglet and rat models of PNALD [23]. Here, we found that L. johnsonii promoted the expression of Cpt1α, while the underlying mechanisms remain to be elucidated.…”

Section: Discussionmentioning

confidence: 78%

“…In our previous studies, we established that TPN infusion for 7 days led to the manifestation of liver steatosis and perturbation in bile acid metabolism in rats [5,13,23]. We first evaluated body weight (Supplementary Figure S1A) and the percentage of liver/body weight (Supplementary Figure S1B).…”

Section: Johnsonii Treatment Alleviates Hepatic Steatosis In Tpn-fed ...mentioning

confidence: 99%

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Lactobacillus johnsonii Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats

Xu,

Zhou,

Cheng

et al. 2023

Metabolites

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Parenteral nutrition (PN), a vital therapy for patients with intestinal failure, can lead to the development of parenteral nutrition-associated liver disease (PNALD). In this study, we aimed to investigate the role of Lactobacillus johnsonii (L. johnsonii) in a rat model of PNALD. Total parenteral nutrition (TPN)-fed rats were used to assess the role of L. johnsonii in liver steatosis, bile acid metabolism, gut microbiota, and hepatocyte apoptosis. We observed a depletion of L. johnsonii that was negatively correlated with the accumulation of glycochenodeoxycholic acid (GCDCA), a known apoptosis inducer, in rats subjected to TPN. L. johnsonii attenuated TPN-induced liver steatosis by inhibiting fatty acid synthesis and promoting fatty acid oxidation. TPN resulted in a decrease in bile acid synthesis and biliary bile secretion, which were partially restored by L. johnsonii treatment. The gut microbial profile revealed depletion of pathogenic bacteria in L. johnsonii-treated rats. L. johnsonii treatment reduced both hepatic GCDCA levels and hepatocyte apoptosis compared with the TPN group. In vitro, L. johnsonii treatment inhibited GCDCA-induced hepatocyte apoptosis via its bile salt hydrolase (BSH) activity. Our findings suggest that L. johnsonii protects against liver steatosis, bile acid dysregulation, and hepatocyte apoptosis in TPN-fed rats.

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Section: Discussionmentioning

confidence: 78%

Section: Johnsonii Treatment Alleviates Hepatic Steatosis In Tpn-fed ...mentioning

confidence: 99%

Lactobacillus johnsonii Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats

Xu,

Zhou,

Cheng

et al. 2023

Metabolites

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“…Among the described amino acids, phenylalanine has been revealed to be the most efficient [ 81 ]. L-arginine reduces oxidative stress and L-Glutamine diminishes inactive energy expenditure [ 82 ]. Niihara [ 83 ] reported a phase 3 trial demonstrating efficacy in reducing acute complications of SCD, leading the FDA to approve pharmaceutical-grade L-glutamine (Endari, Emmaus Medical) as a prescription medication for adults and children aged 5 and above.…”

Section: Functional Food Exploited In Scd Managementmentioning

confidence: 99%

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

Gonçalves,

Smaoui,

Brito

et al. 2024

CIMB

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Sickle cell anemia (SCA), the most common form of sickle cell disease (SCD), is a genetic blood disorder. Red blood cells break down prematurely, causing anemia and often blocking blood vessels, leading to chronic pain, organ damage, and increased infection risk. SCD arises from a single-nucleotide mutation in the β-globin gene, substituting glutamic acid with valine in the β-globin chain. This review examines treatments evaluated through randomized controlled trials for managing SCD, analyzes the potential of functional foods (dietary components with health benefits) as a complementary strategy, and explores the use of bioactive compounds as functional food ingredients. While randomized trials show promise for certain drugs, functional foods enriched with bioactive compounds also hold therapeutic potential. Further research is needed to confirm clinical efficacy, optimal dosages, and specific effects of these compounds on SCD, potentially offering a cost-effective and accessible approach to managing the disease.

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Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery

Bakrey,

Shivgotra,

Abdu

et al. 2024

CDT

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Total Parenteral Nutrition (TPN) is a method of providing nutrients directly into the bloodstream for individuals who are unable to meet their nutritional needs through the normal digestive process or gastrointestinal system. It provides macronutrients and micronutrients in a single container, reducing handling and contamination risks and making it more cost-effective. TPN has the potential to be used as a drug delivery system, with applications in combination therapies, personalized medicine, and integrating advanced technologies. It can enhance drug dosage precision and provide nutritional assistance, potentially reducing hospitalization and improving patient outcomes. However, implementing new applications requires thorough testing and regulatory approval. TPN could be particularly useful in pediatric and geriatric care and could also contribute to global health by combating malnutrition in areas with limited medical resources. Healthcare professionals prepare a sterile solution tailored to each patient's nutritional needs, and administration involves a central venous catheter. However, the simultaneous administration of medications with PN admixtures can result in pharmacological incompatibility, which can impact the stability of the oil-in-water system. The European Society for Clinical Nutrition and Metabolism and the American Society for Parenteral and Enteral Nutrition recommendations advise against including non-nutrient drugs in PN admixtures due to safety concerns. This review focuses on the utilization of Total Parenteral Nutrition (TPN) as a method for delivering drugs. It discusses the benefits and difficulties associated with its commercial application and offers suggestions for future research endeavors.

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Targeted metabolomics unravels altered phenylalanine levels in piglets receiving total parenteral nutrition

Cited by 4 publications

References 32 publications

Lactobacillus johnsonii Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats

Lactobacillus johnsonii Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery

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