Targeted melanoma radiotherapy using ultrasmall 177Lu-labeled α-melanocyte stimulating hormone-functionalized core-shell silica nanoparticles

Zhang, Xiuli; Chen, Feng; Turker, Melik Z.; Ma, Kai; Zanzonico, Pat; Gallazzi, Fabio; Shah, Manankumar A.; Prater, Austin R.; Wiesner, Ulrich; Bradbury, Michelle S.; McDevitt, Michael R.; Quinn, Thomas P.

doi:10.1016/j.biomaterials.2020.119858

Cited by 38 publications

(28 citation statements)

References 43 publications

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“…Optical SRM with aC' dots will therefore enable the direct study, in particular, of intracellular particle processing details in live cells relevant to questions associated with the clinical translation of diagnostic as well as therapeutic C' dot applications. [27,[62][63][64][65]…”

Section: Doi: 101002/adma202006829mentioning

confidence: 99%

Ultrasmall, Bright, and Photostable Fluorescent Core–Shell Aluminosilicate Nanoparticles for Live‐Cell Optical Super‐Resolution Microscopy

et al. 2021

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Section: Doi: 101002/adma202006829mentioning

confidence: 99%

Ultrasmall, Bright, and Photostable Fluorescent Core–Shell Aluminosilicate Nanoparticles for Live‐Cell Optical Super‐Resolution Microscopy

et al. 2021

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“…The most innovative feature of NT B 700 NPs is the ability to be a platform where the fluorescence energy transfer process, known as FRET, occurs at a high efficiency rate. 21 Besides being one of the most used "stealth" polymers in the drug delivery field, polyethylene glycol (PEG), part of NP shell, allows to modulate the type and number of functional groups exposed on NP surface 11,22 . As a consequence, PEG properties lead to the conjugation of several biomolecules on NT B 700 NPs in addition to being the primary interface between NPs and cells, by influencing bio-distribution and toxicity.…”

Section: Introductionmentioning

confidence: 99%

Uptake and Intracellular Trafficking Studies of Multiple Dye-Doped Core-Shell Silica Nanoparticles in Lymphoid and Myeloid Cells

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Introduction Since most biologically active macromolecules are natural nanostructures, operating in the same scale of biomolecules gives the great advantage to enhance the interaction with cellular components. Noteworthy efforts in nanotechnology, particularly in biomedical and pharmaceutical fields, have propelled a high number of studies on the biological effects of nanomaterials. Moreover, the determination of specific physicochemical properties of nanomaterials is crucial for the evaluation and design of novel safe and efficient therapeutics and diagnostic tools. In this in vitro study, we report a physicochemical characterisation of fluorescent silica nanoparticles (NPs), interacting with biological models (U937 and PBMC cells), describing the specific triggered biologic response. Methods Flow Cytometric and Confocal analyses are the main method platforms. However TEM, NTA, DLS, and chemical procedures to synthesize NPs were employed. Results NT B 700 NPs, employed in this study, are fluorescent core-shell silica nanoparticles, synthesized through a micelle-assisted method, where the fluorescence energy transfer process, known as FRET, occurs at a high efficiency rate. Using flow cytometry and confocal microscopy, we observed that NT B 700 NP uptake seemed to be a rapid, concentration-, energy- and cell type-dependent process, which did not induce significant cytotoxic effects. We did not observe a preferred route of internalization, although their size and the possible aggregated state could influence their extrusion. At this level of analysis, our investigation focuses on lysosome and mitochondria pathways, highlighting that both are involved in NP co-localization. Despite the main mitochondria localization, NPs did not induce a significant increase of intracellular ROS, known inductors of apoptosis, during the time course of analyses. Finally, both lymphoid and myeloid cells are able to release NPs, essential to their biosafety. Discussion These data allow to consider NT B 700 NPs a promising platform for future development of a multifunctional system, by combining imaging and localized therapeutic applications in a unique tool.

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“…With the radiochemical stability, biological activity, and high affinity cellular binding properties of 177 Lu-DOTA-αMSH-PEG-C′ dots, efficient tumor uptake and safe metabolic behavior were revealed through SPECT imaging in mice melanoma models. Such C′ dots successfully prolonged the survival period of mice with satisfactory biosafety, paving a new road for nuclear imaging and targeted radionuclide therapy (Zhang et al, 2020).…”

Section: Nanoparticle-enhanced Radiotherapy For Tumor Theranosticsmentioning

confidence: 99%

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

et al. 2021

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Malignant tumors have become one of the major causes of human death, but there remains a lack of effective methods for tiny tumor diagnosis, metastasis warning, clinical efficacy prediction, and effective treatment. In this context, localizing tiny tumors via imaging and non-invasively extracting molecular information related to tumor proliferation, invasion, metastasis, and drug resistance from the tumor microenvironment have become the most fundamental tasks faced by cancer researchers. Tumor-associated microenvironmental physiological parameters, such as hypoxia, acidic extracellular pH, protease, reducing conditions, and so forth, have much to do with prognostic indicators for cancer progression, and impact therapeutic administrations. By combining with various novel nanoparticle-based activatable probes, molecular imaging technologies can provide a feasible approach to visualize tumor-associated microenvironment parameters noninvasively and realize accurate treatment of tumors. This review focuses on the recent achievements in the design of “smart” nanomedicine responding to the tumor microenvironment-related features and highlights state-of- the-art technology in tumor imaging diagnosis and therapy.

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Targeted melanoma radiotherapy using ultrasmall 177Lu-labeled α-melanocyte stimulating hormone-functionalized core-shell silica nanoparticles

Cited by 38 publications

References 43 publications

Ultrasmall, Bright, and Photostable Fluorescent Core–Shell Aluminosilicate Nanoparticles for Live‐Cell Optical Super‐Resolution Microscopy

Ultrasmall, Bright, and Photostable Fluorescent Core–Shell Aluminosilicate Nanoparticles for Live‐Cell Optical Super‐Resolution Microscopy

Uptake and Intracellular Trafficking Studies of Multiple Dye-Doped Core-Shell Silica Nanoparticles in Lymphoid and Myeloid Cells

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

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