“… 13 Reduced colonization of intestinal flora and formula feeding promote toxic bile acid accumulation, exacerbating intestinal injury in severe NEC. 14 Moreover, total bile acid levels in the ileum and NEC incidence/severity are positively correlated, with bile acid reduction upon NEC relief. 15 However, whether NEC can be cured by regulating bile acid metabolism through probiotics or gut microbes remains unclear.…”