Targeted intracellular delivery of photosensitizers

Соболев, А. С.; Jans, David A.; Rosenkranz, Andrey A.

doi:10.1016/s0079-6107(00)00002-x

Cited by 89 publications

(72 citation statements)

References 222 publications

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“…In chemical terms, this necessitates access to unsymmetrical tetrapyrroles that allow the selective connection with a targeting or biologically active group. Many reviews have addressed this question and also indicated the need for better intracellular targeting [83]. Specific subcellular targeting has been possible for PS for over a decade and specific targeting signals have been known for much longer.…”

Section: Targeting and Bioconjugatesmentioning

confidence: 99%

“…Specific subcellular targeting has been possible for PS for over a decade and specific targeting signals have been known for much longer. Especially for chlorin e 6 derivatives many targeted bioconjugates were prepared early on and nuclear targeting alone resulted in an increase in PDT effects by a factor of 10 3 compared to the free drug [83].…”

Section: Targeting and Bioconjugatesmentioning

confidence: 99%

“…Most multicomponent PS-carrier conjugates are chemically complex and require laborious and expensive procedures. One suggestion has been to develop recombinant chimeric vehicles for PS with specific targeting modules [83].…”

Section: Targeting and Bioconjugatesmentioning

confidence: 99%

See 2 more Smart Citations

mTHPC – A drug on its way from second to third generation photosensitizer?

Senge

2012

Photodiagnosis and Photodynamic Therapy

108

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Section: Targeting and Bioconjugatesmentioning

confidence: 99%

Section: Targeting and Bioconjugatesmentioning

confidence: 99%

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mTHPC – A drug on its way from second to third generation photosensitizer?

Senge

2012

Photodiagnosis and Photodynamic Therapy

108

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“…130 Because the mechanism of action of the singlet oxygen generated in PDT is DNA damage and inactivation of enzymes responsible for DNA repair, the logical cellular target for PSs in PDT would be the nucleus. 130,131 The generation of these cytotoxic singlet oxygen species beyond the cell and the ultimate target, the nucleus, leads to reduced efficacy resulting from the short diffusion range of the singlet oxygen. 130 Hence, subcellular delivery, distribution, and accumulation of the PS is fundamental to the efficacy of PDT.…”

mentioning

confidence: 99%

“…130 Hence, subcellular delivery, distribution, and accumulation of the PS is fundamental to the efficacy of PDT. 131 To address this challenge, Ling et al formulated a lipid nanoparticle coated with folate-containing pullulan, which would be stable in plasma and targeted to the overexpressed folate receptor on tumor cells, thereby accumulating preferentially in, and be endocytosed into, tumor cells. 130 Enzymatic degradation of the pullulan-folate coating releases lipid and drug, which form lipid-drug complexes, the lipophilicity of which facilitates transport into the nucleus of the cell.…”

mentioning

confidence: 99%

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Frank¹,

Tyagi²,

Tomar³

et al. 2014

IJN

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Nanotechnology, although still in its infantile stages, has the potential to revolutionize the diagnosis, treatment, and monitoring of disease progression and success of therapy for numerous diseases and conditions, not least of which is cancer. As it is a leading cause of mortality worldwide, early cancer detection, as well as safe and efficacious therapeutic intervention, will be indispensable in improving the prognosis related to cancers and overall survival rate, as well as health-related quality of life of patients diagnosed with cancer. The development of a relatively new field of nanomedicine, which combines various domains and technologies including nanotechnology, medicine, biology, pharmacology, mathematics, physics, and chemistry, has yielded different approaches to addressing these challenges. Of particular relevance in cancer, nanosystems have shown appreciable success in the realm of diagnosis and treatment. Characteristics attributable to these systems on account of the nanoscale size range allow for individualization of therapy, passive targeting, the attachment of targeting moieties for more specific targeting, minimally invasive procedures, and real-time imaging and monitoring of in vivo processes. Furthermore, incorporation into nanosystems may have the potential to reintroduce into clinical practice drugs that are no longer used because of various shortfalls, as well as aid in the registration of new, potent drugs with suboptimal pharmacokinetic profiles. Research into the development of nanosystems for cancer diagnosis and therapy is thus a rapidly emerging and viable field of study.

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Nanoparticles for Photodynamic Therapy of Cancer

Zeisser‐Labouèbe

Vargas

Delié

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Concept and Basis of Photodynamic Therapy and Photodetection Mechanisms of Photodynamic Therapy and Photodiagnosis Selective Tumor Uptake of Photosensitizers Photosensitizers Conventional Photosensitizers New Entities Photodynamic Therapy: Advantages and Limitations Photosensitizer Formulations Non‐biodegradable Nanoparticles for Photodynamic Therapy Metallic Nanoparticles Ceramic Nanoparticles Nanoparticles Made of Non‐biodegradable Polymers Biodegradable Polymeric Nanoparticles for Photodynamic Therapy Preparation of Biodegradable Polymeric Nanoparticles In situ Polymerization Dispersion of a Preformed Polymer “Stealth” Particles Targeted Nanoparticles In Vitro Relevance of Polymeric Nanoparticles in PDT on Cell Models Photodynamic Activity of PS ‐loaded Nanoparticles Uptake and Trafficking of Photosensitizers In Vivo Relevance of Polymeric Nanoparticles in PDT Biodistribution and Pharmacokinetics of Photosensitizers Coupled to Nanoparticles Vascular Effects In Vivo Efficacy on Tumor: Tumor Suppression Effects Adverse Effects Conclusions Acknowledgments

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Targeted intracellular delivery of photosensitizers

Cited by 89 publications

References 222 publications

mTHPC – A drug on its way from second to third generation photosensitizer?

mTHPC – A drug on its way from second to third generation photosensitizer?

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Nanoparticles for Photodynamic Therapy of Cancer

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