Targeted internalization and activation of glycosidic switch liposomes by an EphA2 PEG engager increases therapeutic efficacy against lung cancer
Kai-Wen Ho,
Yen-Ling Liu,
Bo-Cheng Huang
et al.
Abstract:Glycosidic switch liposome (GSL) technology uses a reversible glucuronide ester to efficiently encapsulate and stably retain potent anticancer drugs in liposomes. Parental drug is generated by enzymatic hydrolysis of the glucuronide switch in the lysosomes of target cells. Here we investigated if bispecific molecules simultaneously targeting polyethylene glycol (PEG) on GSL and an internalizing tumor antigen could increase uptake of GSL into cancer cells and enhance anticancer activity. A bispecific PEG engage… Show more
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