Targeted intelligent mesoporous polydopamine nanosystems for multimodal synergistic tumor treatment

Yang, Jiaxin; Zeng, Wenbin; Fu, Xiaoxue; Chen, Lu; Yu, Xiaojuan; Xu, Ping; Huang, Wenyan; Feng, Lu; Yang, Zhangyou

doi:10.1039/d2tb00973k

Cited by 7 publications

(2 citation statements)

References 47 publications

(55 reference statements)

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“…Glycosides are well-known to exhibit important pharmacological activities. 2 3 4 Pertinent examples include inhibitors of various glycoproteins, 5 glycosides with anticarcinogenic activities, 6 novel glycosidic flavonoids acting as antioxidant and antibiotic agents, 7 compounds that regulate body fluid, etc. 8…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on the Synthesis of C-Glycosides from 1,2-Glycals

Mukherjee,

Kundu,

Das

et al. 2023

Synthesis

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The development of stereoselective synthetic routes for C-glycosides has attracted immense attention from carbohydrate chemists in the last two decades. In this review, progress made in the last decade towards the synthesis of C-glycosides using glycals as a precursor are discussed. Glycals have been extensively manipulated to generate oxocarbenium cation or glycosyl anion to form C-C bond at the anomeric position through attack with C-nucleophiles or transition metal catalyzed coupling reactions. Recent reports on carbon Ferrier, intramolecular Cope, Claisen rearrangements, various coupling reactions in the presence or absence of directing groups are deliberated herein. Contemporary applications of these reactions in the syntheses of natural products, drugs and scaffolds with bioactive potential are briefly discussed.

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Section: Introductionmentioning

confidence: 99%

Recent Advances on the Synthesis of C-Glycosides from 1,2-Glycals

Mukherjee,

Kundu,

Das

et al. 2023

Synthesis

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“…Such as the small interfering Ribonucleic acid (siRNA), which has great promising in the treatment of cancer and viral infectious diseases, has poor stability in biological media and their inability to diffuse across cell membranes are huge obstacles to developing siRNA-based therapies ( Zandanel et al, 2020 ). Yang et al (2022a) established an intelligent nanoparticle delivery system by curing the mesoporous-mesoporous polydopamine (MPDA) and gambogic acid (GA), and siRNA with PCMs together. PCMs can effectively avoid siRNA inactivation and accidental release of GA has targeted accumulation at the tumor site.…”

Section: Introductionmentioning

confidence: 99%

Applications of phase change materials in smart drug delivery for cancer treatment

Bao

et al. 2022

Front. Bioeng. Biotechnol.

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Phase change materials (PCMs) are materials that are stimulated by the external enthalpy change (temperature) to realize solid-liquid and liquid-solid phase transformation. Due to temperature sensitivity, friendly modification, and low toxicity, PCMs have been widely used in smart drug delivery. More often than not, the drug was encapsulated in a solid PCMs matrix, a thermally responsive material. After the trigger implementation, PCMs change into a solid-liquid phase, and the loading drug is released accordingly. Therefore, PCMs can achieve precise release control with different temperature adjustments, which is especially important for small molecular drugs with severe side effects. The combination of drug therapy and hyperthermia through PCMs can achieve more accurate and effective treatment of tumor target areas. This study briefly summarizes the latest developments on PCMs as smart gate-keepers for anti-tumor applications in light of PCMs becoming a research hot spot in the nanomedicine sector in recent years.

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Multifunctional composite phase change materials: Preparation, enhanced properties and applications

Li,

Zhao,

et al. 2024

Composites Part A: Applied Science and Manufacturing

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Targeted intelligent mesoporous polydopamine nanosystems for multimodal synergistic tumor treatment

Abstract: In this work, we obtained targeted smart mesoporous polydopamine delivery systems (PPMD@GA/si) for gene-mediated photochemotherapy of tumors through a combinatorial strategy.

Cited by 7 publications

References 47 publications

Recent Advances on the Synthesis of C-Glycosides from 1,2-Glycals

Recent Advances on the Synthesis of C-Glycosides from 1,2-Glycals

Applications of phase change materials in smart drug delivery for cancer treatment

Multifunctional composite phase change materials: Preparation, enhanced properties and applications

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