Targeted increase in cerebral blood flow by transcranial near‐infrared laser irradiation

Uozumi, Yoichi; Nawashiro, Hiroshi; Sato, Shunichi; Kawauchi, Satoko; Shima, Katsuji; Kikuchi, Makoto

doi:10.1002/lsm.20938

Cited by 121 publications

(82 citation statements)

References 39 publications

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“…LED therapy is noninvasive, painless and non-thermal. 36 Each participant received 18 treatments (Monday, Wednesday, and Friday, minimum of 48 h between treatments), for 6 weeks.…”

Section: Screening Cognitive Testingmentioning

confidence: 99%

“…The effect of the light is non-thermal. 36 Multiple animal studies using mice, show significantly better recovery of motor and cognitive function after NIR transcranial low-level laser therapy when treated in the acute post-injury phase. [37][38][39][40] Most of this work has suggested improved energy kinetics and decreased inflammation as possible mechanisms for acute neuroprotection.…”

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confidence: 99%

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Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Naeser

Zafonte²,

Krengel³

et al. 2014

Journal of Neurotrauma

225

204

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This pilot, open-protocol study examined whether scalp application of red and near-infrared (NIR) light-emitting diodes (LED) could improve cognition in patients with chronic, mild traumatic brain injury (mTBI). Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine triphosphate (ATP) important for cellular metabolism. Nitric oxide is released locally, increasing regional cerebral blood flow. LED therapy is noninvasive, painless, and non-thermal (cleared by the United States Food and Drug Administration [FDA], an insignificant risk device). Eleven chronic, mTBI participants (26-62 years of age, 6 males) with nonpenetrating brain injury and persistent cognitive dysfunction were treated for 18 outpatient sessions (Monday, Wednesday, Friday, for 6 weeks), starting at 10 months to 8 years post-mTBI (motor vehicle accident [MVA] or sports-related; and one participant, improvised explosive device [IED] blast injury). Four had a history of multiple concussions. Each LED cluster head (5.35 cm diameter, 500 mW, 22.2 mW/cm 2 ) was applied for 10 min to each of 11 scalp placements (13 J/cm 2 ). LEDs were placed on the midline from front-to-back hairline; and bilaterally on frontal, parietal, and temporal areas. Neuropsychological testing was performed pre-LED, and at 1 week, and 1 and 2 months after the 18th treatment.

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“…LED therapy is noninvasive, painless and non-thermal. 36 Each participant received 18 treatments (Monday, Wednesday, and Friday, minimum of 48 h between treatments), for 6 weeks.…”

Section: Screening Cognitive Testingmentioning

confidence: 99%

mentioning

confidence: 99%

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Naeser

Zafonte²,

Krengel³

et al. 2014

Journal of Neurotrauma

225

204

View full text Add to dashboard Cite

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“…Compelling evidence of the in vivo neuroprotective effects of LLLT against transient ischemia has been provided by recent studies conducted by Uozumi et al; 86 LLLT delivered transcranially was able to increase cerebral blood flow. LLLT was given at 808 nm and 0.8 W/cm 2 , 1.6 W/cm 2 , and 3.2 W/ cm 2 for 45 minutes over an exposure field of 3 mm in one hemisphere.…”

Section: Stroke and Neurotraumamentioning

confidence: 99%

Low-level light therapy of the eye and brain

Rojas¹,

González-Lima²

2011

116

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Low-level light therapy (LLLT) using red to near-infrared light energy has gained attention in recent years as a new scientific approach with therapeutic applications in ophthalmology, neurology, and psychiatry. The ongoing therapeutic revolution spearheaded by LLLT is largely propelled by progress in the basic science fields of photobiology and bioenergetics. This paper describes the mechanisms of action of LLLT at the molecular, cellular, and nervous tissue levels. Photoneuromodulation of cytochrome oxidase activity is the most important primary mechanism of action of LLLT. Cytochrome oxidase is the primary photoacceptor of light in the red to near-infrared region of the electromagnetic spectrum. It is also a key mitochondrial enzyme for cellular bioenergetics, especially for nerve cells in the retina and the brain. Evidence shows that LLLT can secondarily enhance neural metabolism by regulating mitochondrial function, intraneuronal signaling systems, and redox states. Current knowledge about LLLT dosimetry relevant for its hormetic effects on nervous tissue, including noninvasive in vivo retinal and transcranial effects, is also presented. Recent research is reviewed that supports LLLT potential benefits in retinal disease, stroke, neurotrauma, neurodegeneration, and memory and mood disorders. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain.

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“…After 180 min of reperfusion, the neck incision was closed, and the mice were allowed to recover. We previously con fi rmed that mice without the posterior communicating artery showed low residual CBF (less than 30 % of pre-occlusion values) in the same hemisphere during BCCAO by performing an anatomical study [ 6 ] . Therefore, mice that showed low residual CBF (less than 30 % of pre-occlusion values) in the same hemisphere were included from further analysis.…”

Section: Bccao Modelmentioning

confidence: 99%

The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion

Nagatani

Takeuchi

Kobayashi

et al. 2013

Acta Neurochirurgica Supplement

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In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a nontraumatic aneurysm clip. The mice were divided into three groups: sham, BCCAO, and BCCAO treated with 1.3 % hydrogen gas. Cerebral blood flow (CBF) in the cortex was measured sequentially for both hemispheres with a non--invasive and noncontact laser Doppler blood perfusion imager during the procedure. Vital signs were also recorded. Oxidative stress evaluated by measuring the level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), neuronal injury in the hippocampal CA1 sector, and brain water content were assessed 24 h after ischemia. The hydrogen gas treatment had no significant effect on vital signs or CBF values. However, the reduction of the expression of 8-OHdG, the decrease in the neuronal injury in the hippocampal CA1 sector, and the attenuation in brain water content were observed in hydrogen-treated mice. In conclusion, hydrogen gas might be effective in a mouse BCCAO model.

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Targeted increase in cerebral blood flow by transcranial near‐infrared laser irradiation

Abstract: Our data suggest that NIR laser irradiation is a promising experimental and therapeutic tool in the field of cerebral circulation research.

Cited by 121 publications

References 39 publications

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Significant Improvements in Cognitive Performance Post-Transcranial, Red/Near-Infrared Light-Emitting Diode Treatments in Chronic, Mild Traumatic Brain Injury: Open-Protocol Study

Low-level light therapy of the eye and brain

The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion

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