Targeted Gold Nanoparticle–Oligonucleotide Contrast Agents in Combination with a New Local Voxel-Wise MRI Analysis Algorithm for In Vitro Imaging of Triple-Negative Breast Cancer

Chauhan, Rajat; El-Baz, Nagwa; Keynton, Robert; James, Kurtis T.; Malik, Danial A.; Zhu, Min; El‐Baz, Ayman; Ng, Chin K.; Bates, Paula J.; Malik, Mohammad Tariq; O’Toole, Martin G.

doi:10.3390/nano9050709

Cited by 21 publications

(12 citation statements)

References 57 publications

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“…The nanoparticles composites (FeO/Si core and Au shell composite) can be used in case of in vivo and composite materials that served as double contrast agents for computed tomography and MRI, which showed good computed tomography attenuation and gave better results of magnetic resonance in hepatoma (Gunko, 2016). Chauhan et al (2019) proved that Gd-Au nanocomposite can be used for dynamic multimodal imaging as contrast agents. Zhang W.-H. et al (2016) studied the dye-loaded fluorescence imaging with Si nanoparticles in both in vivo and in vitro conditions.…”

Section: Bioimaging Applicationmentioning

confidence: 95%

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

et al. 2020

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Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal-and metal oxide-supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.

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Section: Bioimaging Applicationmentioning

confidence: 95%

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

et al. 2020

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“…Multifunctional nanoprobes have unique physical and chemical properties that allow high resolution imaging 35 , 36 . Some inorganic nanoparticles are effective contrast agents for various imaging modes, such as Fe 3 O 4 nanoparticles for MRI and Au nanoparticles for computed tomography (CT) and photoacoustic imaging (PAI) 37 , 38 . Surface modification of these nanoparticles can additionally endow them with histocompatibility, stability and targeting capacity 39 .…”

Section: Image-guided Immunotherapymentioning

confidence: 99%

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Yang¹,

Guan²,

Zhang³

2021

Theranostics

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Immunotherapy is an effective tumor treatment strategy that has several advantages over conventional methods such as surgery, radiotherapy and chemotherapy. Studies show that multifunctional nanoprobes can achieve multi-mode image-guided multiple tumor treatment modes. The tumor cells killed by chemotherapies or phototherapies release antigens that trigger an immune response and augment the effects of tumor immunotherapy. Thus, combining immunotherapy and multifunctional nanoprobes can achieve early cancer diagnosis and treatment. In this review, we have summarized the current research on the applications of multifunctional nanoprobes in image-guided immunotherapy. In addition, image-guided synergistic chemotherapy/photothermal therapy/photodynamic therapy and immunotherapy have also been discussed. Furthermore, the application potential and clinical prospects of multifunctional nanoprobes in combination with immunotherapy have been assessed.

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“…The Raman reporter was anchored on the surface of AuNR through a double Au–S bond, which was more stable than the single Au–S bond in the highly reductive tumor microenvironment. , The hydroxyl group of Raman reporter would increase the hydrophilicity of the AuNR surface. Two aptamers (AS1411 or MUC1) were chosen as the targeting moieties for specific recognition of nuclelin and mucin-1 proteins which are overexpressed on many types of cancer cells, for instance, MCF-7 cells. , The oligonucleotide C-con was designed by replacing guanosine of AS1411 aptamer with cytidine which is widely used for control sequence for AS1411 . The oligonucleotide T-con was formed as a poly-thymidine sequence that did not form any structure by itself.…”

mentioning

confidence: 99%

Bioorthogonal SERS Nanotags as a Precision Theranostic Platform for in Vivo SERS Imaging and Cancer Photothermal Therapy

et al. 2020

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Precise detection and effective treatment are crucial to prolong cancer patients' lives. Surface-enhanced Raman scattering (SERS) imaging coupled with photothermal therapy has been considered a precise and effective strategy for cancer theranostics. Nevertheless, Raman reporters employed in the literature usually possessed multiple shift peaks in the fingerprint region, which are overlapped with background signals from endogenous biological molecules. Herein, we fabricated a new kind of bioorthogonal Raman reporter and aptamer functionalized SERS nanotags. The SERS nanotags demonstrated a strong Raman signal at 2205 cm −1 in the biologically Raman-silent region and recognized MCF-7 breast cancer cells for Raman imaging with high specificity. Laser irradiation induced serious toxicity of MCF-7 cells due to the excellent photothermal capability of the SERS nanotags. After intravenous administration of the SERS nanotags, tumor Raman spectral detection and mapping in living mice were successfully achieved. Further in vivo antitumor experiments manifested that the aptamer-modified SERS nanotags significantly restrained tumor growth after laser irradiation with 99% inhibition rate and good biocompatibility. These results clearly revealed that the SERS nanotags could serve as a novel and precise theranostic platform for in vivo cancer diagnosis and photothermal therapy.P recise diagnosis and effective treatment are crucial to enhance cancer patients' survival rates and quality of life. Nevertheless, conventional detection approaches of cancer including biopsy, ultrasonography, X-ray computed tomography (CT), and magnetic resonance imaging (MRI) suffer from inherent drawbacks such as low sensitivity and specificity which restrict their clinical applications in early diagnosis. 1−3 Another emerging imaging technique known as positron emission tomography (PET) combined with CT or MRI has demonstrated higher sensitivity and accuracy than traditional imaging methods but requires high cost and radioactive materials with potential health hazards. 4,5 In recent years, surface-enhanced Raman scattering (SERS) imaging has attracted tremendous attention in biomedical fields, owing to its ultrahigh sensitivity (up to 10 −15 M), high signal-tobackground ratio, specific fingerprint signature, photostability, and excellent multiplex capability. 6−12 These advantages give SERS imaging great promise for accurate cancer detection. 13−17 In 2008, Nie's group first employed SERS nanotags for cancer targeting and spectroscopic detection in xenograft tumor models. 18 Gambhir et al. first applied spectrally unique SERS nanotags for in vivo deep-tissue multiplex imaging. 19,20 Subsequently, they designed a novel nanotag with triple modality imaging capability and utilized SERS imaging to distinguish the brain tumor margin in surgical resection. 21 Recently, they presented a small-animal Raman imaging system for rapid, wide-area, high-spatial resolution and spectroscopic imaging. 22 Kircher et al. has demonstrated that SERS nanotagguided sur...

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Targeted Gold Nanoparticle–Oligonucleotide Contrast Agents in Combination with a New Local Voxel-Wise MRI Analysis Algorithm for In Vitro Imaging of Triple-Negative Breast Cancer

Cited by 21 publications

References 57 publications

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Bioorthogonal SERS Nanotags as a Precision Theranostic Platform for in Vivo SERS Imaging and Cancer Photothermal Therapy

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