Targeted drug delivery for maternal and perinatal health: Challenges and opportunities

Sharma, Anjali; Sah, Nirnath; Kannan, Sujatha; Kannan, Rangaramanujam M.

doi:10.1016/j.addr.2021.113950

Cited by 19 publications

(6 citation statements)

References 204 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pharmacological properties such as absorption into blood, distribution, metabolism, and liberation in a timely manner may be affected. Through proper formulation, these properties may be modified to aid in extending the half-life of a drug, reducing the drug dose, and minimizing off-target effects [ 94 , 95 , 96 ]. Numerous reports discuss the ease of maternal-to-fetal transfer of drugs using nanoparticle technology, including different nanoformulation categories such as lipid-based drug delivery systems, polymeric nanoformulations, dendrimers, etc.…”

Section: Vaginal Nanoformulations To Block Premature Cervix Remodelin...mentioning

confidence: 99%

Vaginal Nanoformulations for the Management of Preterm Birth

et al. 2022

View full text Add to dashboard Cite

Preterm birth (PTB) is a leading cause of infant morbidity and mortality in the world. In 2020, 1 in 10 infants were born prematurely in the United States. The World Health Organization estimates that a total of 15 million infants are born prematurely every year. Current therapeutic interventions for PTB have had limited replicable success. Recent advancements in the field of nanomedicine have made it possible to utilize the vaginal administration route to effectively and locally deliver drugs to the female reproductive tract. Additionally, studies using murine models have provided important insights about the cervix as a gatekeeper for pregnancy and parturition. With these recent developments, the field of reproductive biology is on the cusp of a paradigm shift in the context of treating PTB. The present review focuses on the complexities associated with treating the condition and novel therapeutics that have produced promising results in preclinical studies.

show abstract

Section: Vaginal Nanoformulations To Block Premature Cervix Remodelin...mentioning

confidence: 99%

Vaginal Nanoformulations for the Management of Preterm Birth

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Pharmacological properties such as absorption into blood, distribution, metabolism and liberation in a timely manner may be affected. Through proper formulation, these properties may be modified to aid in extending the half-life of a drug, reducing the drug dose and minimizing off-target effects [93][94][95]. Numerous literature reports discuss the ease of maternal-to-fetal transfer of drugs using nanoparticle technology, including different nanoformulation catego-ries such as lipid-based drug delivery systems, polymeric nanoformulations, dendrimers etc.…”

Section: Advantages Of Vaginal Nanoformulationsmentioning

confidence: 99%

Vaginal Nanoformulations for the Management of Preterm Birth

Mir¹,

Patel²,

Vartak³

et al. 2022

Preprint

View full text Add to dashboard Cite

Preterm birth is a leading cause of infant morbidity and mortality in the world. In 2020, 1 in 10 infants were born prematurely in the United States. Globally, the World Health Or-ganization estimates 15 million infants are born prematurely. The efficacy of current ther-apeutic interventions for preterm birth have been called into question due to limited repli-cable success. Recent advancements in the field of nanomedicine have made it possible to utilize the vaginal administration route to effectively and locally deliver drugs to the fe-male reproductive tract. Also, studies using murine models have provided important in-sights about the cervix as a gatekeeper for pregnancy and parturition. It seems plausible that the field of reproductive biology is on the cusp of a paradigm shift in the context of treating preterm birth. The present review focuses on the complexities associated with treating the condition and novel therapeutics that have produced promising results in pre-clinical studies.

show abstract

“…Системы доставки лекарств c применением нанотехнологий рассматриваются как способ улучшения общей эффективности местных анестетиков, что включает в себя модернизацию химических подходов для обеспечения повышенного проникновения медикаментов в ткани или же для содействия поверхностной анестезии [2]. В том числе, одним из важных и перспективных преимуществ использования адресной доставки лекарств при помощи нанотехнологий является потенциальная возможность повысить безопасность терапии для пациентов репродуктивного возраста, а также обеспечить надлежащее лечение с уменьшением рисков для беременной женщины и плода [3]. Проще говоря, системы доставки в области наномедицины разрешают найти альтернативные стратегии целенаправленного лекарственного вмешательства (например, адресная доставка лекарств к плоду в случае аритмий может минимизировать побочные эффекты для матери).…”

Section: перспективы применения нанотехнологий для целевой доставки лекарственных средств в травматологииunclassified

Перспективы Применения Нанотехнологий Для Целевой Доставки Лекарственных Средств В Травматологии

Курочкин¹,

Лысенко²

2021

Scientific Practice: Modern and Classical Research Methods

View full text Add to dashboard Cite

Targeted drug delivery for maternal and perinatal health: Challenges and opportunities

Cited by 19 publications

References 204 publications

Vaginal Nanoformulations for the Management of Preterm Birth

Vaginal Nanoformulations for the Management of Preterm Birth

Vaginal Nanoformulations for the Management of Preterm Birth

Перспективы Применения Нанотехнологий Для Целевой Доставки Лекарственных Средств В Травматологии

Contact Info

Product

Resources

About