Targeted DNA sequencing to identify genetic aberrations in glioblastoma that underlie venous thromboembolism; a cohort study

Kapteijn, Maaike Y.; Kaptein, Fleur H.J.; Stals, Milou A.M.; Klaase, Eva E; García-Ortiz, Inés; Eijk, Ronald van; Ruano, Dina; Duinen, Sjoerd G. van; Cannegieter, Suzanne C.; Taphoorn, Martin J.B.; Dirven, Linda; Koekkoek, Johan A F; Klok, Frederikus A.; Versteeg, Henri H.; Buijs, Jeroen T.

doi:10.1016/j.thromres.2022.11.013

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…There is evidence that several uncommon hereditary diseases, such as tuberous sclerosis and neurofibromatosis types 1 and 2, are becoming more common. 26…”

Section: Family Historymentioning

confidence: 99%

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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“…There is evidence that several uncommon hereditary diseases, such as tuberous sclerosis and neurofibromatosis types 1 and 2, are becoming more common. 26…”

Section: Family Historymentioning

confidence: 99%

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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“…Activation of the Epidermal Growth Factor Receptor (EGFR), through genomic amplifications or mutations, was reported to be positively correlated with F3 expression in GBM [13]. A significant positive association between the amplification status of the EGFR locus in GBM and the presence of histologically detectable intra-tumoral thrombosis was suggested by Furuta et al [14]; however, the link between VTE and the presence of EGFR amplifications in GBM nevertheless remains uncertain [15,16]. In addition to specific genomic alterations, chromosomal instability also activates innate immune pathways, potentially leading to F3 expression in human tumors [17].…”

Section: Introductionmentioning

confidence: 99%

An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas

Saidak,

Laville,

Soudet

et al. 2024

Cancers

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Venous thromboembolic events are frequent complications of Glioblastoma Multiforme (GBM) and low-grade gliomas (LGGs). The overexpression of tissue factor (TF) plays an essential role in the local hypercoagulable phenotype that underlies these complications. Our aim was to build an MRI radiomics model for the non-invasive exploration of the hypercoagulable status of LGG/GBM. Radiogenomics data from The Cancer Genome Atlas (TCGA) and REMBRANDT (Repository for molecular BRAin Neoplasia DaTa) cohorts were used. A logistic regression model (Radscore) was built in order to identify the top 20% TF-expressing tumors, considered to be at high thromboembolic risk. The most contributive MRI radiomics features from LGG/GBM linked to high TF were identified in TCGA using Least Absolute Shrinkage and Selection Operator (LASSO) regression. A logistic regression model was built, whose performance was analyzed with ROC in the TCGA/training and REMBRANDT/validation cohorts: AUC = 0.87 [CI95: 0.81–0.94, p < 0.0001] and AUC = 0.78 [CI95: 0.56–1.00, p = 0.02], respectively. In agreement with the key role of the coagulation cascade in gliomas, LGG patients with a high Radscore had lower overall and disease-free survival. The Radscore was linked to the presence of specific genomic alterations, the composition of the tumor coagulome and the tumor immune infiltrate. Our findings suggest that a non-invasive assessment of the hypercoagulable status of LGG/GBM is possible with MRI radiomics.

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CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress

Zhang,

Shi,

et al. 2024

Life Sciences

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Targeted DNA sequencing to identify genetic aberrations in glioblastoma that underlie venous thromboembolism; a cohort study

Cited by 5 publications

References 48 publications

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas

CP41, a novel curcumin analogue, induces apoptosis in endometrial cancer cells by activating the H3F3A/ proteasome-MAPK signaling pathway and enhancing oxidative stress

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