Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations
Alexandra M. Haugh,
Robert C. Osorio,
Rony A. Francois
et al.
Abstract:Background: Cutaneous melanoma (CM) can be molecularly classified into four groups: BRAF mutant, NRAS mutant, NF1 mutant and triple wild-type (TWT) tumors lacking any of these three alterations. In the era of immune checkpoint inhibition (ICI) and targeted molecular therapy, the clinical significance of these groups remains unclear. Here, we integrate targeted DNA sequencing with comprehensive clinical follow-up in CM patients. Methods: This was a retrospective cohort study that assessed clinical and molecular… Show more
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