Targeted Diagnostic Radiopharmaceuticals: Design Options for Small‐Molecule Radiotracers

Insights into Peptidoglycan-Targeting Radiotracers for Imaging Bacterial Infections: Updates, Challenges, and Future Perspectives

“…Therefore, optimization of the biodistribution profile using different structural modifications needs to be explored. It is worth mentioning that the lengthy and complex chemical and chemo-enzymatic procedures during the synthesis of peptido­glycan-based precursors leave a small room for structural manipulations. ,, A plausible solution to mitigate these challenges and fast-track the development process requires the use of computational tools such as docking and high-throughput screening to create chemical libraries with diverse molecular adaptations that will predict how structural, chemical, physical, and physicochemical properties of molecules can alter the net cellular uptake through interaction with target enzymes and the pharmacokinetic profiling. ,− …”