Targeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta

Li, Xue; Liu, Dan; Zhao, Lijie; Wang, Linlin; Li, Yuanmin; Cho, Kenka; Tao, Chuanmin; Jiang, Baohong

doi:10.1016/j.lfs.2019.116927

Cited by 29 publications

(26 citation statements)

References 32 publications

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“…Another study on acute TBAD patients found that the percentage of CD14 + monocytes was significantly higher than that of normal volunteers, in which the percentages of the two monocyte subsets (CD14 bright CD16 − and CD14 bright CD16 + ) were increased significantly (P < 0.001) (16). Furthermore, selective depletion of monocyte/macrophage in mice model dramatically reduced the incidence of aortic dissection, supporting that monocytes/ macrophages have an important role in the pathophysiology of aortic dissection (27).…”

Section: Discussionmentioning

confidence: 92%

Association Between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection

Xie

Yang

Luo

et al. 2022

Front. Cardiovasc. Med.

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Aims: The monocyte to high-density lipoprotein ratio (MHR), a novel marker of inflammation and cardiovascular events, has recently been found to facilitate the diagnosis of acute aortic dissection. This study aimed to assess the association of preoperative MHR with in-hospital and long-term mortality after thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection (TBAD).Methods: We retrospectively evaluated 637 patients with acute TBAD who underwent TEVAR from a prospectively maintained database. Multivariable logistic and cox regression analyses were conducted to assess the relationship between preoperative MHR and in-hospital as well as long-term mortality. For clinical use, MHR was modeled as a continuous variable and a categorical variable with the optimal cutoff evaluated by receiver operator characteristic curve for long-term mortality. Propensity score matching was used to diminish baseline differences and subgroups analyses were conducted to assess the robustness of the results.Results: Twenty-one (3.3%) patients died during hospitalization and 52 deaths (8.4%) were documented after a median follow-up of 48.1 months. The optimal cutoff value was 1.13 selected according to the receiver operator characteristic curve (sensitivity 78.8%; specificity 58.9%). Multivariate analyses showed that MHR was independently associated with either in-hospital death [odds ratio (OR) 2.11, 95% confidence interval (CI) 1.16-3.85, P = 0.015] or long-term mortality [hazard ratio (HR) 1.78, 95% CI 1.31-2.41, P < 0.001). As a categorical variable, MHR > 1.13 remained an independent predictor of in-hospital death (OR 4.53, 95% CI 1.44-14.30, P = 0.010) and long-term mortality (HR 4.16, 95% CI 2.13-8.10, P < 0.001). Propensity score analyses demonstrated similar results for both in-hospital death and long-term mortality. The association was further confirmed by subgroup analyses.Conclusions: MHR might be useful for identifying patients at high risk of in-hospital and long-term mortality, which could be integrated into risk stratification strategies for acute TBAD patients undergoing TEVAR.

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Section: Discussionmentioning

confidence: 92%

Association Between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection

Xie

Yang

Luo

et al. 2022

Front. Cardiovasc. Med.

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“…Clinically, AD risk factors are broadly divided into two categories; (I) conditions that weaken the composition of the elastic and/or muscle fibers of the aortic media layer, termed medial degeneration (II) situations that increase aortic wall stress, the best known is hypertension that present in more than two‐thirds of AD patients 5 . Recently, experimental and clinical studies have revealed that immune inflammatory mechanisms have crucial roles not only in the presence but also in the progression of AD 6–8 . Several biomarkers used to weigh inflammatory response have been investigated as contributors to diagnosis or risk prediction of AD.…”

Section: Introductionmentioning

confidence: 99%

Monocyte to high‐density lipoprotein ratio at hospital admission predicts intrahospital mortality in patients with Stanford type‐A dissection

Savaş

Aslan

Kizilay

et al. 2022

Journal of Cardiac Surgery

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Background Immune inflammatory mechanisms have crucial roles not only in the presence but also in the progression of aortic dissection (AD). Monocyte count to high‐density lipoprotein ratio (MHR) has recently emerged as an indicator of inflammation and oxidative stress. Thus, we aimed to examine the prognostic value of MHR in patients with AD. Methods A total of 204 consecutive patients with Stanford type‐A dissection who managed surgically were retrospectively enrolled in the present study. Recruited patients were divided into two groups according to the occurrence of intrahospital death; Group 1 consisted of 165 patients who were discharged alive, and Group 2 consisted of 39 patients who died during index hospitalization. Two groups were compared with respect to baseline clinical data and admission laboratory parameters including MHR. Results The mean age of the Group 1 was 55.2 ± 12.3 years, while the mean age of the Group 2 was 60.6 ± 10.8 years (p = .012). The patients who were discharged alive (Group 1) had significantly lower MHR than the deceased patients (Group 2) (0.02099 ± 0.00140 vs. 0.02848 ± 0.01513, p = .004). At receiver operating characteristics curve analysis, MHR = 0.020699 had 67% sensitivity and 59% specificity in predicting intrahospital mortality among patients with AD. In multivariate analysis, MHR was found to be an independent risk factor of intrahospital mortality among those (β = 1.094, p = .011). Conclusion MHR is an inexpensive and easily calculated biomarker, which is useful to predict intrahospital mortality in patients with Stanford type‐A dissection who managed surgically.

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“… 22 , 31 , 32 , 33 , 34 , 35 , 36 However, it has been more common to administer BAPN in the drinking water for young mice (age, 3-4 weeks). A few studies have used BAPN administration via a gastric tube, 26 diet, 12 , 37 or intraperitoneal injection. 38 …”

Section: Development Of Bapn-induced Aad In Micementioning

confidence: 99%

“…Although the common routes of BAPN administration have been subcutaneous infusion using an osmotic pump or drinking water, other routes have also been reported, including administration via the diet, 12 , 37 gastric tube, 26 or intraperitoneal injection. 38 Adding BAPN to the mouse diet had effects similar to that of administering the compound via the drinking water.…”

Section: Development Of Bapn-induced Aad In Micementioning

confidence: 99%

β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

Sawada

Beckner

Ito

et al. 2022

JVS-Vascular Science

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The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissection. This mouse model mimics several facets of the pathology of human aortic aneurysms and dissection, although many variables exist in the experimental design and protocols that must be resolved to determine its application to the human disease. In the present brief review, we have introduced the development of this mouse model and provided insights into understanding its pathologic features.

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Targeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta

Cited by 29 publications

References 32 publications

Association Between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection

Association Between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection

Monocyte to high‐density lipoprotein ratio at hospital admission predicts intrahospital mortality in patients with Stanford type‐A dissection

β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

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