Targeted Delivery with Peptidomimetic Conjugated Self-Assembled Nanoparticles

Abstract

Peptides produce specific nanostructures, making them useful for targeting in biological systems but they have low bioavailability, potential immunogenicity and poor metabolic stability. Peptidomimetic self-assembled NPs can possess biological recognition motifs as well as providing desired engineering properties. Inorganic NPs, coated with self-assembled macromers for stability and anti-fouling, and conjugated with target-specific ligands, are advancing imaging from the anatomy-based level to the molecular level. Ligand conjugated NPs are attractive for cell-selective tumor drug delivery, since this process has high transport capacity as well as ligand dependent cell specificity. Peptidomimetic NPs can provide stronger interaction with surface receptors on tumor cells, resulting in higher uptake and reduced drug resistance. Self-assembled NPs conjugated with peptidomimetic antigens are ideal for sustained presentation of vaccine antigens to dendritic cells and subsequent activation of T cell mediated adaptive immune response. Self-assembled NPs are a viable alternative to encapsulation for sustained delivery of proteins in tissue engineering. Cell penetrating peptides conjugated to NPs are used as intracellular delivery vectors for gene expression and as transfection agents for plasmid delivery. In this work, synthesis, characterization, properties, immunogenicity, and medical applications of peptidomimetic NPs in imaging, tumor delivery, vaccination, tissue engineering, and intracellular delivery are reviewed.

Amphiphilic Block Co-polyesters Bearing Pendant Cyclic Ketal Groups as Nanocarriers for Controlled Release of Camptothecin

“…[45]. Cancer cells develop resistance to chemotherapy by adapting to cellular stress and toxic insults via the increased drug efflux, decreased drug influx, DNA repair activation, detoxification and blockage of apoptosis [46]. It is not surprising that our nanoparticle formulations, consisting of single active drug component without the specific targeting modality and co-factors or modulators, are not efficient in combating drug resistance [47].…”

Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates

“…Other peptide-related nanoparticles, such as peptide aptamers and peptidomimetic self-assembled nanoparticles, also have shown great potential in targeted drug delivery. The former are more frequently used directly as drugs interfering with the function of receptors [128], while the later have more expanded applications in tumor imaging, tumor-targeting delivery and vaccination [129]. The use of these peptides has increased the specificity and efficacy of drug delivery while reducing side effects [130, 131].…”

Prodrug Conjugate Strategies in Targeted Anticancer Drug Delivery Systems

“…Furthermore, peptidomimetic selfassembled nanoparticles and peptide aptamers, which are peptide-related nanoparticles, also have shown great promise in targeted drug delivery. The former have wider applications in tumor imaging, tumor targeting delivery and vaccination [ 58 ], whereas the latter are directly used as drugs interfering with the function of receptors [ 59 ]. The use of these peptides has assisted in enhancing the specifi city and effi cacy of drug delivery with reduced side effects [ 60 , 61 ].…”