Targeted delivery to the nucleus☆

Pouton, Colin W.; Wagstaff, Kylie M.; Roth, Daniela; Moseley, Gregory W.; Jans, David A.

doi:10.1016/j.addr.2007.06.010

Cited by 224 publications

(173 citation statements)

References 225 publications

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“…These reagents are, however, not optimal for in vivo applications due to lack of selectivity towards target cells and high toxicity. Liposomes (Fretz et al 2005), nanoparticles (Vasir & Labhasetwar 2007), polymers (Neu et al 2005) and viruses (Pouton et al 2007) are today investigated as formulation principles for intracellular delivery of macromolecular drugs. Endo/lysosomal sequestration and subsequent degradation is, however, also shown to be an obstacle for these delivery systems.…”

Section: Photochemical Internalization (Pci)mentioning

confidence: 99%

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

Weyergang

Selbo

Berg

2006

Journal of Controlled Release

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Section: Photochemical Internalization (Pci)mentioning

confidence: 99%

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

Weyergang

Selbo

Berg

2006

Journal of Controlled Release

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“…[147] Flierl et al used another approach to overcome the size limitations. In this work, an MTS peptide-peptide nucleic acid (PNA) conjugate was annealed to an oligonucleotide with a complementary PNA sequence and the complex was Linear polymer [177] α,β-Importins Nuclear localization signals (NLSs) [167,168,174,175] CGYGPKKKRKVGG Micelles [18] DRQIKIWFQNRRM-KWKK Nanoparticles [178] PKKRKV Nanoparticles [179] CVKRKKKP Linear polymers [63,79] Cytoplasmic NFkB Linear polymers [180,181] (11 of 26) 1700022 transferred into the cytosol using a PEI carrier. While the carrier allowed endosomal escape, the MTS targeting peptide directed the oligonucleotide to the mitochondria.…”

Section: Mitochondrial Deliverymentioning

confidence: 99%

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Battistella

Klok

2017

Macromolecular Bioscience

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Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer‐based nanocarriers allow to increase plasma half‐life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well‐defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.

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“…2a) or via IMPa in the context of an IMPa/b heterodimer ( Fig. 2b) (Palmeri & Malim, 1999;Pouton et al, 2007). IMPb mediates docking and translocation of cargo-IMP complexes through the NPC via transient interactions with FxFG repeats in Nups that line the pore (Bayliss et al, 2000).…”

Section: Protein Nuclear Importmentioning

confidence: 99%

Roles of nuclear trafficking in infection by cytoplasmic negative-strand RNA viruses: paramyxoviruses and beyond

Audsley

Jans

Moseley

2016

Journal of General Virology

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Genome replication and virion production by most negative-sense RNA viruses (NSVs) occurs exclusively in the cytoplasm, but many NSV-expressed proteins undergo active nucleocytoplasmic trafficking via signals that exploit cellular nuclear transport pathways. Nuclear trafficking has been reported both for NSV accessory proteins (including isoforms of the rabies virus phosphoprotein, and V, W and C proteins of paramyxoviruses) and for structural proteins. Trafficking of the former is thought to enable accessory functions in viral modulation of antiviral responses including the type I IFN system, but the intranuclear roles of structural proteins such as nucleocapsid and matrix proteins, which have critical roles in extranuclear replication and viral assembly, are less clear. Nevertheless, nuclear trafficking of matrix protein has been reported to be critical for efficient production of Nipah virus and Respiratory syncytial virus, and nuclear localization of nucleocapsid protein of several morbilliviruses has been linked to mechanisms of immune evasion. Together, these data point to the nucleus as a significant host interface for viral proteins during infection by NSVs with otherwise cytoplasmic life cycles. Importantly, several lines of evidence now suggest that nuclear trafficking of these proteins may be critical to pathogenesis and thus could provide new targets for vaccine development and antiviral therapies.

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Targeted delivery to the nucleus☆

Cited by 224 publications

References 225 publications

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Roles of nuclear trafficking in infection by cytoplasmic negative-strand RNA viruses: paramyxoviruses and beyond

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