Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

Berries polyphenols: Nano-delivery systems to improve their potential in cancer therapy

“…QUE-ZnCPX markedly decreased BFTC-905 cells viability, motility and invasive capability in a dose-dependent manner through MT1-MMP and p-AKT down-regulation [36], while PBA-QUE-ZnCPX was able to reduce tumor growth in EAC bearing mice accompanied by lower associated toxicity in kidney, liver and spleen [11]. QUE release from the PBA-QUE-ZnCPX was pH sensitive; the amount released at 48 h was almost 47, 28 and 13%, at pH 5.0, 6.0 and 7.4, respectively [11]. Metal oxide NPs are a good choice among NPs for drug delivery, since they have tunable size and shape, surface chemistry and express wide range of oxidation states [11,36].…”

“…In human BFTC-905 bladder cancer cells [36] and Subcutaneous Ehrlich Ascites Carcinoma (EAC) mice model, QUE-zinc complex (QUE-ZnCPX) or phenylboronic acid (PBA)-QUE-ZnCPX [11] also showed enhanced anti-cancer and anti-metastasis efficacies compared to free-QUE. QUE-ZnCPX markedly decreased BFTC-905 cells viability, motility and invasive capability in a dose-dependent manner through MT1-MMP and p-AKT down-regulation [36], while PBA-QUE-ZnCPX was able to reduce tumor growth in EAC bearing mice accompanied by lower associated toxicity in kidney, liver and spleen [11]. QUE release from the PBA-QUE-ZnCPX was pH sensitive; the amount released at 48 h was almost 47, 28 and 13%, at pH 5.0, 6.0 and 7.4, respectively [11].…”

“…However, despite their potential chemopreventive and therapeutic activities, different pharmacokinetic, preclinical and clinical studies revealed significant shortcomings, such as non-specific tumor targeting [11], low bioavailability and consequent controversial efficacy [2,7,11,12], which limit their application in therapeutics. For example, the estimated maximum plasma concentration (Cmax) and the time required to reach this Cmax for anthocyanins is about 10 -3 M and :<1-1.5 h, respectively [7].…”

“…Low bioavailability has been related to poor absorption throughout the gastrointestinal tract (GT) (in their native form) and extensive metabolization by phase I/II detoxification enzymes and colonic microbiota, which lead to a wide range of new chemical structures before reaching their site of action [2,7]. In order to solve these problems and improve stability and/or bioavailability of berries phenolic compounds, nano-delivery systems have been proposed as effective tools that permit their effective transport in the tumor tissue [7,11,13,14].…”

Fluorescent Terpolymers via In Situ Allocation of Aliphatic Fluorophore Monomers: Fe(III) Sensor, High‐Performance Removals, and Bioimaging

“…After appropriate seeding, MDCK and HOS cells were treated with variable concentrations of terpolymers. After 72 h of incubation, 3‐(4, 5‐dimethylthiazolyl‐2)‐2, 5‐diphenyltetrazolium bromide (MTT) assay was performed to check the viability of cells following the reported protocol . The assay was performed thrice, i.e., technical replicate n = 3, independently.…”