Targeted Delivery of Immunomodulators to Lymph Nodes

Azzi, Jamil; Yin, Qian; Uehara, Mayuko; Ohori, Shunsuke; Tang, Li; Cai, Kaimin; Ichimura, Takaharu; McGrath, Martina M.; Maarouf, Omar H.; Kefaloyianni, Eirini; Loughhead, Scott; Jarolím, Petr; Sun, Qidi; Kwon, Mincheol; Tullius, Stefan G.; Andrian, Ulrich H. von; Cheng, Jianjun; Abdi, Reza

doi:10.1016/j.celrep.2016.04.007

Cited by 78 publications

(52 citation statements)

References 57 publications

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“…Overall, a successful translocation of DCs' membrane onto PLGA‐NP and a stable biomimetic structure of mini DC were affirmed, ensuring the feasibility of subsequent experiments. Of special note, possessing an average diameter of <200 nm might also facilitate its free trafficking to the lymph nodes (Figure S5B, Supporting Information) …”

Section: Resultsmentioning

confidence: 99%

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

Cheng

Jin

et al. 2020

Advanced Science

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Ovarian cancer is the most lethal gynecological malignancy with high recurrence rates and low survival rates, remaining a disease of high unmet need. Cancer immunotherapy, which harnesses the potential of the immune system to attack tumors, has emerged as one of the most promising treatment options in recent years. As an important form of immunotherapy, dendritic cell (DC)–based vaccines have demonstrated the ability to induce an immune response, while clinical efficacy of DC vaccines remains unsubstantiated as long‐term benefit is only reported in a restricted proportion of patients. Here, a biomimetic nanovaccine derived from DCs is developed through cell membrane coating nanotechnology. This nanovaccine, denoted “mini DC,” inherits the ability of antigen presentation and T cells' stimulation from DCs and is shown to elicit enhanced activation of T cells both in vitro and in vivo. In a mouse model of ovarian cancer, mini DCs exhibit superior therapeutic and prophylactic efficacy against cancer including delayed tumor growth and reduced tumor metastasis compared with DC vaccine. These findings suggest that mini DCs may serve as a facile and potent vaccine to boost anticancer immunotherapy.

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Section: Resultsmentioning

confidence: 99%

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

Cheng

Jin

et al. 2020

Advanced Science

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“…No evidence of systemic toxicity was observed with either formulation. Other work has loaded peptide antigens in PLG NPs to improve long-term engraftment of bone marrow in mice by changing how the antigen is processed [97], while MPs containing an immunosuppressive drug have been coated with LN-targeting antibodies to prolong survival in a heart allograft model [98]. …”

Section: Biomaterials Improve Targeting Selectivity and Potency Of mentioning

confidence: 99%

Improving Vaccine and Immunotherapy Design Using Biomaterials

Bookstaver

Tsai

Bromberg

et al. 2018

Trends in Immunology

151

110

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“…146 In a similar approach, PEG-coated ultrasmall superparamagnetic iron oxide NPs were targeted to mouse LEC by coupling them with anti-lymphatic vessel endothelial hyaluronan receptor-1 antibody, 147 which specifically targeted LEC. 146 In a similar approach, PEG-coated ultrasmall superparamagnetic iron oxide NPs were targeted to mouse LEC by coupling them with anti-lymphatic vessel endothelial hyaluronan receptor-1 antibody, 147 which specifically targeted LEC.…”

Section: Nanoparticles and Microparticlesmentioning

confidence: 99%

“…These NPs were formulated to incorporate tacrolimus, focusing the immunosuppressive molecule into the dLN, inducing immunosuppression and prolonging cardiac allograft survival. 146 In a similar approach, PEG-coated ultrasmall superparamagnetic iron oxide NPs were targeted to mouse LEC by coupling them with anti-lymphatic vessel endothelial hyaluronan receptor-1 antibody, 147 which specifically targeted LEC.…”

Section: Nanoparticles and Microparticlesmentioning

confidence: 99%

Role of lymph node stroma and microenvironment in T cell tolerance

Saxena

Paluskievicz

et al. 2019

Immunological Reviews

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Lymph nodes (LNs) are at the cross roads of immunity and tolerance. These tissues are compartmentalized into specialized niche areas by lymph node stromal cells (LN SCs). LN SCs shape the LN microenvironment and guide immunological cells into different zones through establishment of a CCL19 and CCL21 gradient. Following local immunological cues, LN SCs modulate activity to support immune cell priming, activation, and fate. This review will present our current understanding of LN SC subsets roles in regulating T cell tolerance. Three major types of LN SC subsets, namely fibroblastic reticular cells, lymphatic endothelial cells, and blood endothelial cells, are discussed. These subsets serve as scaffolds to support and regulate T cell homeostasis. They contribute to tolerance by presenting peripheral tissue antigens to both CD4 and CD8 T cells. The role of LN SCs in regulating T cell migration and tolerance induction is discussed. Looking forward, recent advances in bioengineered materials and approaches to leverage LN SCs to induce T cell tolerance are highlighted, as are current clinical practices that allow for manipulation of the LN microenvironment to induce tolerance. Increased understanding of LN architecture, how different LN SCs integrate immunological cues and shape immune responses, and approaches to induce T cell tolerance will help further combat autoimmune diseases and graft rejection.

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Targeted Delivery of Immunomodulators to Lymph Nodes

Cited by 78 publications

References 57 publications

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

Improving Vaccine and Immunotherapy Design Using Biomaterials

Role of lymph node stroma and microenvironment in T cell tolerance

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