Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells

Rady, Tony; Erb, Stéphane; Deddouche-Grass, Safia; Morales, Renaud; Chaubet, Guilhem; Cianférani, Sarah; Basse, Nicolas; Wagner, Alain

doi:10.1016/j.isci.2024.109068

iScience

2024

DOI: 10.1016/j.isci.2024.109068

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Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells

Tony Rady,

Stéphane Erb,

Safia Deddouche-Grass

et al.

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Cited by 2 publications

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Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies

Rady,

Lehot,

Most

et al. 2024

STAR Protocols

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Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies

Rady,

Lehot,

Most

et al. 2024

STAR Protocols

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Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA

Ripoll,

Cahuzac,

Dovgan

et al. 2024

Bioconjugate Chem.

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RNA interference is a widely used biological process by which double-stranded RNA induces sequence-specific gene silencing by targeting mRNA for degradation. However, the physicochemical properties of siRNAs make their delivery extremely challenging, thus limiting their bioavailability at the target site. In this context, we developed a versatile and selective siRNA delivery system of a trastuzumab-conjugated nanocarrier. These immunoconjugates consist of the assembly by electrostatic interactions of an oligonucleotide-modified antibody with a cationic micelle for the targeted delivery of siRNA in HER2-overexpressing cancer cells. Results show that, when associated with the corresponding siRNA at the appropriate N/P ratio, our supramolecular assembly was able to efficiently induce luciferase and PLK-1 gene silencing in a cell-selective manner in vitro.

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Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells

Cited by 2 publications

References 48 publications

Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies

Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies

Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA

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