Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages

Soto, Ernesto; O’Connell, Olivia; Dikengil, Fusun; Peters, Paul J.; Clapham, Paul R.; Ostroff, Gary R.

doi:10.1155/2016/8520629

Cited by 39 publications

(31 citation statements)

References 27 publications

(34 reference statements)

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“…Such macrophage-targeted nanoparticles have been developed to inhibit virus replication (24, 25). Monocyte-derived macrophage (MDM)-targeting nanoparticles containing conventional antiretroviral therapy have been reported to lengthen the activities and efficacies of existing therapies against HIV-1 infection with less toxicity (26, 27). …”

Section: Introductionmentioning

confidence: 99%

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages

Choi

Britigan

Narayanasamy

2017

Antimicrob Agents Chemother

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Treatment of individuals coinfected with human immunodeficiency virus (HIV) type 1 and Mycobacterium tuberculosis is challenging due to the prolonged treatment requirements, drug toxicity, and emergence of drug resistance. Mononuclear phagocytes (MP; macrophages) are one of the natural reservoirs for both HIV and M. tuberculosis. Here, the treatment of HIV and M. tuberculosis coinfection was studied by preloading human macrophages with MP-targeted gallium (Ga) nanoparticles to limit subsequent simultaneous infection with both HIV and M. tuberculosis. Ga nanoparticles provided sustained drug release for 15 days and significantly inhibited the replication of both HIV and M. tuberculosis. Addition of Ga nanoparticles to MP already infected with M. tuberculosis or HIV resulted in a significant decrease in the magnitude of these infections, but the magnitude was less than that achieved with nanoparticle preloading of the MP. In addition, macrophages that were coinfected with HIV and M. tuberculosis and that were loaded with Ga nanoparticles reduced the levels of interleukin-6 (IL-6) and IL-8 secretion for up to 15 days after drug loading. Ga nanoparticles also reduced the levels of IL-6 and IL-8 secretion by ionomycin- and lipopolysaccharide-induced macrophages, likely by modulating the IκB kinase-β/NF-κB pathway. Delivery of Ga nanoparticles to macrophages is a potent long-acting approach for suppressing HIV and M. tuberculosis coinfection of macrophages in vitro and sets the stage for the development of new approaches to the treatment of these important infections.

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Section: Introductionmentioning

confidence: 99%

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages

Choi

Britigan

Narayanasamy

2017

Antimicrob Agents Chemother

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“…pH-dependent endosomal escape of the nanoparticles into the cell cytoplasm resulted in inhibition of viral protease [ 179 ]. Soto et al, prepared glucan particles loaded with gallium nanoparticles for delivery of gallium and inhibition of HIV infection in macrophages [ 180 ]. The formulation inhibited 95% HIV growth when compared to the free gallium nanoparticles.…”

Section: Viral Infectionsmentioning

confidence: 99%

“…The formulation inhibited 95% HIV growth when compared to the free gallium nanoparticles. Gallium nanoparticles lack specificity and loading the nanoparticles onto carriers resulted in efficient targeted delivery of the nanoparticles to macrophages by a receptor-mediated uptake mechanism [ 180 ].…”

Section: Viral Infectionsmentioning

confidence: 99%

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

2017

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Infectious diseases can be transmitted and they cause a significant burden on public health globally. They are the greatest world killers and it is estimated that they are responsible for the demise of over 17 million people annually. The impact of these diseases is greater in the developing countries. People with compromised immune systems and children are the most affected. Infectious diseases may be caused by bacteria, viruses, and protozoa. The treatment of infectious diseases is hampered by simultaneous resistance to multiple drugs, indicating that there is a serious and pressing need to develop new therapeutics that can overcome drug resistance. This review will focus on the recent reports of metal-based nanoparticles that are potential therapeutics for the treatment of infectious diseases and their biological efficacy (in vitro and in vivo).

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“…YPs are 3–5 μm hollow and porous microspheres, a byproduct of the food grade yeast ( Saccharomyces cerevisae ) extract manufacturing process. We have used yeast particles for the encapsulation of a broad range of molecules for drug delivery and agricultural applications [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes

Mirza

Soto

et al. 2020

Molecules

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Soil-transmitted nematodes (STN) infect 1–2 billion of the poorest people worldwide. Only benzimidazoles are currently used in mass drug administration, with many instances of reduced activity. Terpenes are a class of compounds with anthelmintic activity. Thymol, a natural monoterpene phenol, was used to help eradicate hookworms in the U.S. South circa 1910. However, the use of terpenes as anthelmintics was discontinued because of adverse side effects associated with high doses and premature stomach absorption. Furthermore, the dose–response activity of specific terpenes against STNs has been understudied. Here we used hollow, porous yeast particles (YPs) to efficiently encapsulate (>95%) high levels of terpenes (52% w/w) and evaluated their anthelmintic activity on hookworms (Ancylostoma ceylanicum), a rodent parasite (Nippostrongylus brasiliensis), and whipworm (Trichuris muris). We identified YP–terpenes that were effective against all three parasites. Further, YP–terpenes overcame albendazole-resistant Caenorhabditis elegans. These results demonstrate that terpenes are broad-acting anthelmintics. Terpenes are predicted to be extremely difficult for parasites to resist, and YP encapsulation provides water-suspendable terpene materials without surfactants and sustained terpene release that could lead to the development of formulations for oral delivery that overcome fast absorption in the stomach, thus reducing dosage and toxic side effects.

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Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages

Cited by 39 publications

References 27 publications

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes

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