Targeted Delivery of Drugs to the Colon

Philip, Anil K.; Zingales, Sarah K.

doi:10.1002/9781118833322.ch18

Cited by 2 publications

(2 citation statements)

References 76 publications

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“…23 The punishment associated with an incestuous or adulterous affair was often a curse or even death (Deut 27:20; 22:22, 24, 30). 24 However, as it was the tradition of Israel to deal with people who commit grievous sins by removing them from the community (Deut. 17:2-7), Paul, according to Sean McDonough, reflected on this injunction when he prescribed the punishment for the incestuous man.…”

Section: Literary Critical Analysis Of 1 Corinthians 5:1-13mentioning

confidence: 99%

Leadership and Morality in 1 Corinthians 5:1-13: Lessons for Contemporary Ghanaian Church Polity

Ossom-Batsa

Nsiah

2022

PAJOT

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Paul’s response to the issue of sexual immorality in the Corinthian community has attracted the attention of several biblical scholars. While some think that the judgment of Paul on the incestuous man in 1 Corinthians 5:1-13 concerns the identity of the Christian community and moral responsibility, others argue that the focus is on the church’s response to immorality. The present study, on the other hand, through a literary critical analysis of the text, with close attention to its semantics and allusions, and an assessment of the material in the light of its social and historical background, establishes that the absence of a ‘functional leadership’ in the Corinthian Church in the absence of its founder, Paul, to provide an authoritative guide to members exacerbated their moral decadence. The paper concludes that contemporary Ghanaian church polity can learn participatory and shared leadership, which will foster group cohesion, promote the unity of purpose, and heal discord within Church communities.

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Section: Literary Critical Analysis Of 1 Corinthians 5:1-13mentioning

confidence: 99%

Leadership and Morality in 1 Corinthians 5:1-13: Lessons for Contemporary Ghanaian Church Polity

Ossom-Batsa

Nsiah

2022

PAJOT

View full text Add to dashboard Cite

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“…Corollary to this is the pursuit of ways to target cytotoxic agents to cancer with enhanced concentrations. Such approaches include antibody-drug conjugates [ 1 ], nanoparticle-based delivery [ 2 ], and small molecule-drug conjugates [ 3 ] among others [ 4 ], which take advantage of the specific recognition of cell surface biomarkers for targeted delivery. Homing in on an intracellular target has been challenging for obvious reasons.…”

Section: Introductionmentioning

confidence: 99%

Homing in on an intracellular target for delivery of loaded nanoparticles functionalized with a histone deacetylase inhibitor

et al. 2017

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Functionalized nanoparticles (NPs) are usually used to enhance cellular penetration for targeted drug delivery that can improve efficacy and reduce side effects. However, it is difficult to exploit intracellular targets for similar delivery applications. Herein we describe the targeted delivery of functionalized NPs by homing in on an intracellular target, histone deacetylases (HDACs). Specifically, a modified poly-lactide-co-glycolideacid (FPLGA) was yielded by conjugation with an HDAC inhibitor. Subsequently, FPLGA was used to prepare functionalized FPLGA NPs. Compared to unmodified NPs, FPLGA NPs were more efficiently uptaken or retained by MCF-7 cells and showed longer retention time intracellular. In vivo fluorescence imaging also revealed that they had a higher accumulation and a slower elimination than unmodified NPs. FPLGA NPs loaded with paclitaxel exhibited superior anticancer efficacy compared with unmodified NPs. These results offer a promising approach for intracellular drug delivery through elevating the concentration of NPs.

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Targeted Delivery of Drugs to the Colon

Cited by 2 publications

References 76 publications

Leadership and Morality in 1 Corinthians 5:1-13: Lessons for Contemporary Ghanaian Church Polity

Leadership and Morality in 1 Corinthians 5:1-13: Lessons for Contemporary Ghanaian Church Polity

Homing in on an intracellular target for delivery of loaded nanoparticles functionalized with a histone deacetylase inhibitor

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