Abstract:Background and Purpose: Cytokine storm invoked during acute and chronic
lung injury promotes alveolar damage and remodeling. The current study
shows that degraded elastin-targeted nanoparticles releasing doxycycline
(Doxy NPs) are potent in mitigating cytokines storm, migration of immune
cells in the lungs, and inhibiting inflammasome pathways in the LPS
mouse model. Experimental Approach: Cytokine storm and lung injury were
induced using LPS and elastase in C57BL/6 mice (rodent model for
emphysema). The mice … Show more
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