Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)

Structural analysis of doxorubicin-polymer conjugates

“…Samples containing 0.06 ml of the above drug solution and various polymer solutions were mixed to obtain final polymer concentrations ranging from 1 to 60 with constant drug content (40 The fluorescence spectra were 7 Sanyakamdhorn et al, Doxorubicin-polymer recorded at λ ex = 480 nm and λ em from 500 to 750 nm. The intensity of the band at 592 nm from doxorubicin and its analogue [23] was used to calculate the binding constant (K) as reported [24,25].…”

“…Nanoparticle therapeutics based on synthetic polymers offer new routes to improved cancer drug delivery with watersoluble polymers aiding in drug solubility, increasing the therapeutic process through long circulation and increasing uptake into tumors by the enhanced permeability and retention effect [1][2][3]. Among synthetic polymers, poly (ethylene glycol) (PEG), mPEG-dendrimers and dendrimers show potential applications in gene and drug delivery [4][5][6][7][8]. Polyethylene glycols are non-toxic, water-soluble polymers that, owing to their hydrodynamic volume create a shield around the pegylated drug, thus protecting drug from renal clearance, enzymatic degradation and cell recognition cell in the immune system.…”

Novel delivery approaches for cancer therapeutics

“…These enzymes can degrade the basement membrane and natural extracellular matrix opening up more space for tumor growth. MMP-2 and MMP-9 are highly expressed in some malignant tissues such as breast, colon and brain tumors [151]. Elevated concentrations of MMP in tumor tissues can lead to proteolytic degradation of peptide linkages conjugated to drugs and/or delivery systems.…”

Cyto/hemocompatible magnetic hybrid nanoparticles (Ag2S–Fe3O4) with luminescence in the near-infrared region as promising theranostic materials

“…Superparamagnetic iron oxide nanoparticles (SPIONs) [1][2][3][4] and luminescent semiconductor quantum dots (QDs) [5][6][7] have been widely studied for medical and biological applications such as diagnostics, therapy and labeling. SPIONs have been particularly utilized as contrast agents in MRI for both vascular and organ imaging [2,3].…”