Targeted delivery of doxorubicin and vincristine to lymph cancer: evaluation of novel nanostructured lipid carriers <i>in vitro</i> and <i>in vivo</i>

Dong, Xiaoyuan; Wang, Wen; Qu, Hui; Han, Dong Keun; Zheng, Jie; Sun, Guangbin

doi:10.3109/10717544.2015.1041580

Cited by 38 publications

(17 citation statements)

References 23 publications

(21 reference statements)

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“…The high loading capacity of NLCs formulation has offered multiple solutions to such problem, as it was possible to collectively incorporate a combination of chemotherapeutic agents in the same NLC particle. This approach can be used not only to control the release of both drugs, but also to enhance their anticancer effect through their integrated influence [91]. For example, Dong et al prepared NLCs containing a combination of doxorubicin (DOX) and vincristine (VCR) to overcome drug resistance after chemotherapy and the potential for relapses in lymph cancer.…”

Section: Applications Of Nlcs In Delivery Of Chemotherapeutic Agentsmentioning

confidence: 99%

“…This prolonged release was accompanied by a sustained antitumor effect during tumor progression. DOX-NLC, VCR-NLC, DOX-VCR-NLC, and drug solution were compared in lymph cancer animal model and the results showed that DOX-VCR-NLC exhibited more controlled release with synergistic effects and potent anti-tumor activity which was demonstrated by the inhibition of B-cell lymphoma [91].…”

Section: Applications Of Nlcs In Delivery Of Chemotherapeutic Agentsmentioning

confidence: 99%

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Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

et al. 2020

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The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotechnology has revolutionized the pharmaceutical industry and attracted increasing attention as a significant means for optimizing the delivery of chemotherapeutic agents and enhancing their efficiency and safety profiles. Nanostructured lipid carriers (NLCs) are lipid-based formulations that have been broadly studied as drug delivery systems. They have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs) due to their enhanced physical stability, improved drug loading capacity, and biocompatibility. This review focuses on the latest advances in the use of NLCs as drug delivery systems and their preparation and characterization techniques with special emphasis on their applications as delivery systems for chemotherapeutic agents and different strategies for their use in tumor targeting.

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Section: Applications Of Nlcs In Delivery Of Chemotherapeutic Agentsmentioning

confidence: 99%

Section: Applications Of Nlcs In Delivery Of Chemotherapeutic Agentsmentioning

confidence: 99%

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

et al. 2020

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“…In the study, based on some previous reports by other researchers, 36 we designed and carried out pre experimental research. We set the ratios of VCR/DOX (1:1, 3:1, 5:1) to study the inhibitory effect of A549 cell under different ratios.…”

Section: Preparation Of Npsmentioning

confidence: 99%

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Zhang

Kong

Jie

et al. 2017

IJN

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Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-in-water double-emulsion solvent diffusion-evaporation method. Chitosan-alginate nanoparticles carrying DOX (CS-ALG-DOX NPs) with a smaller diameter of about 20 nm formed S-D1 NPs; vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-modified poly(lactic-co-glycolic acid) nanoparticles carrying VCR (TPGS-PLGA-VCR NPs) with a larger diameter of about 200 nm constituted L-D2 NPs. Some CS-ALG-DOX NPs loaded into TPGS-PLGA-VCR NPs formed CS-ALG-DOX@TPGS-PLGA-VCR NPs. Under the acidic environment of cytosol and endosome or lysosome in MDR cell, CS-ALG-DOX@TPGS-PLGA-VCR NPs released VCR and CS-ALG-DOX NPs. VCR could arrest cell cycles at metaphase by inhibiting microtubule polymerization in the cytoplasm. After CS-ALG-DOX NPs escaped from endosome, they entered the nucleus through the nuclear pore and released DOX in the intra-nuclear alkaline environment, which interacted with DNA to stop the replication of MDR cells. These results indicated that S-D1@L-D2 NPs was a co-delivery system of intracellular precision release loaded drugs with pH-sensitive characteristics. S-D1@L-D2 NPs could obviously enhance the in vitro cytotoxicity and the in vivo anticancer efficiency of co-delivery drugs, while reducing their adverse effects. Overall, S-D1@L-D2 NPs can be considered an innovative platform for the co-delivery drugs of clinical combination chemotherapy for the treatment of MDR tumor.

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“…Moreover, the utilisation of cyclophosphamide and vincristine potentially inhibit the metastases during two months of the observed periods. Cyclophosphamide is the alkylating agent that able to bind the DNA and depress the DNA replication and mitosis (Prajapati et al, 2017), and vincristine binds the tubulin to inhibit cell's metaphase (Dong et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Mixed Mammary Carcinosarcoma in Domesticated Asian Palm Civet (Paradoxurus hermaphroditus).

Prakoso¹,

Widyawati²,

Wirjaatmadja³

et al. 2019

jwpr

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A female Asian palm civet (Paradoxurus hermaphroditus), three years old was carried for a medical checkup to Ruddy animal's clinic in Sidoarjo, East Java, Indonesia. The civet suffers enlargement of abdominal mammary glands, painless lump, asymmetric size (4.1 and 8.4 cm in diameter), and lacerated wound on the large one with severe haemorrhage. The unilateral mastectomy was conducted under anaesthesia to handles both haemorrhage and tumour mass. Following the surgery, the tumour mass was stored in 10% neutral buffer formalin for histopathology using Hematoxylin & Eosin (H&E) staining and immunohistochemistry against antibody, anti-CD4+ and CD8+, further, a blood sample collected before and after surgery (on days: 0, 7, 30, and 60) for representing the healing progress. The chemotherapy was given using the combination of oral cyclophosphamide and intravenous injection of vincristine. According to laboratory results, the final diagnosis was mixed mammary carcinosarcoma with minimal expression of CD8+, notwithstanding, it showed the better prognosis after surgery and chemotherapy.

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Targeted delivery of doxorubicin and vincristine to lymph cancer: evaluation of novel nanostructured lipid carriers in vitro and in vivo

Cited by 38 publications

References 23 publications

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Mixed Mammary Carcinosarcoma in Domesticated Asian Palm Civet (Paradoxurus hermaphroditus).

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