Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity
Jiahao Shi,
Bin Ma,
Yuhe Zhang
et al.
Abstract:Cancer therapy is a global biomedical challenge, and
a number of
promising anticancer therapeutics, such as small-molecule drugs, proteins,
nucleic acids, photothermal agents, etc., have been
developed or are in development. However, the direct administration
of anticancer therapeutics often fails to achieve the desired therapeutic
efficacy due to their low bioavailability and poor tissue selectivity,
leading to relapse or severe side effects such as immunosuppression,
chronic inflammatory responses, mutagenes… Show more
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