2005
DOI: 10.1161/01.res.0000196559.63223.aa
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Targeted Deletion of Kv4.2 Eliminates I to,f and Results in Electrical and Molecular Remodeling, With No Evidence of Ventricular Hypertrophy or Myocardial Dysfunction

Abstract: Abstract-Previous studies have demonstrated a role for voltage-gated K ϩ (Kv) channel ␣ subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K ϩ current, I to,f , channels. Biochemical studies suggest that mouse ventricular I to,f channels reflect the heteromeric assembly of Kv4.2 and Kv4.3 with the accessory subunits, KChIP2 and Kv␤1, and that Kv4.2 is the primary determinant of regional differences in (mouse ventricular) I to,f densities. Interestingly,… Show more

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Cited by 133 publications
(180 citation statements)
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“…Repolarization to potentials negative to Ϫ50 mV is typically required to restore channel availability. A-type currents have a widespread distribution and are abundantly expressed in neurons and cardiac and smooth muscle cells, where they are thought to play many important physiological roles (2,(7)(8)(9)(10)(11).…”
mentioning
confidence: 99%
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“…Repolarization to potentials negative to Ϫ50 mV is typically required to restore channel availability. A-type currents have a widespread distribution and are abundantly expressed in neurons and cardiac and smooth muscle cells, where they are thought to play many important physiological roles (2,(7)(8)(9)(10)(11).…”
mentioning
confidence: 99%
“…I A has also been demonstrated to limit the back propagation of action potentials into the dendritic arbor (14), to impact long term potentiation in CA1 hippocampal neurons (15), to affect neuronal excitability in the visual cortex (16), and to modulate compartmentalization of membrane excitability in distal dendritic spines (17). Fast transient K ϩ currents in cardiac muscles contribute both to myocyte excitability (18) and to the fast repolarization phase of the cardiac action potential (2,8,19,20). Finally, the pharmacological block of channels that carry fast transient currents in gastrointestinal smooth muscle in mice supports the conclusion that the window currents carried by these channels contribute to the resting membrane potential and cellular excitability of smooth muscle (21,22).…”
mentioning
confidence: 99%
“…In contrast with the global increases in transcript expression with hypertrophy, transcript expression of the I to,f channel ␣ subunits Kv4.2 (KCND2) and Kv4.3 (KCND3) 19,24 was not significantly different in TAC and sham LV, and expression of the I to,f channel accessory subunit KChIP2 (KCNIP2) 24 was actually slightly lower in TAC LV ( Figure 5C). The expression of transcripts encoding I K1 channel ␣ subunits Kir2.1 (KCNJ2) and Kir2.2 (KCNJ12), 23 and of the K2P channel subunit TASK1 (KCNK3), which has been suggested to underlie I ss in rat cardiomyocytes, 26 as well as TASK2 (KCNK5), was unaffected in TAC LV ( Figure 5C).…”
Section: Molecular Basis Of K ؉ Current Remodeling In Tac LVmentioning
confidence: 87%
“…19 Biotinylation of isolated LV myocytes was used to examine cell surface protein expression. Protein quantification was performed with the BCA Protein Assay Kit (Pierce).…”
Section: Biochemical Analysesmentioning
confidence: 99%
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