Targeted concurrent chemoradiotherapy, by using improved microcapsules that release carboplatin in response to radiation, improves detectability by computed tomography as well as antitumor activity while reducing adverse effect in vivo

In this paper, we used microcapsules releasing liposome-protamine-hyaluronic acid nanoparticles (LPH-NP) with/without carboplatin in response to radiation to image and treat MM48 breast cancer in C3He/N mice in two radiation sessions. The micro-particle-induced X-ray emission (PIXE) camera and quantitative PIXE were used to image and measure the release of nanoparticles from the microcapsules. In session one, iopamiron and computed tomography (CT)-detectable microcapsules containing P-selectin and LPH-NP were mixed with a solution of alginate, hyaluronate, ascorbate, and P-selectin. This solution was sprayed into an FeCl2 solution containing VEGFR-1/2 antibodies (Abs). The microcapsules obtained were injected intravenously into mice, and after 9 h, the mice were exposed to 10 or 20 Gy (140 keV) of X-ray radiation. Anti-VEGFR-1/VEGFR-2 microcapsules accumulated around tumors and released P-selectin and the iopamiron-labeled LPH-NP in response to the first radiation. The iopamiron-containing nanoparticles were detected by CT, allowing detection of MM48 tumors by CT. In the second session, the microcapsules released LPH-NH that delivered carboplatin into the tumor cells. This treatment had a significant antitumor effect [Formula: see text]. The micro-PIXE camera and quantitative PIXE successfully imaged and measured the release of contents from microcapsules. Our results indicate that targeted nanoparticles allow for accurate detection and treatment of tumors.

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Development of particle induced X-ray emission-computed tomography in Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency

Satoh

2015

Int. J. PIXE

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A new micro-particle induced X-ray emission-computed tomography (PIXE-CT) system was developed at Takasaki Ion Accelerators for Advanced Radiation Application in Japan Atomic Energy Agency. In this system, scanning transmission ion microscopy-CT was performed as well as PIXE-CT for three-dimensional (3D) measurement of major elements' distributions, which are required for corrections of X-ray yields due to energy losses of projectiles and absorption of X-rays. Moreover, maximum likelihood expectation maximization algorithm has been introduced to image reconstruction because higher spatial resolution can be obtained even with less X-ray yields. Consequently, 3D distribution of trace elements in a minute biological cell less than 100 μm has been successfully obtained.

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Targeted concurrent chemoradiotherapy, by using improved microcapsules that release carboplatin in response to radiation, improves detectability by computed tomography as well as antitumor activity while reducing adverse effect in vivo

Cited by 6 publications

References 26 publications

Preclinical imaging and translational animal models of cancer for accelerated clinical implementation of nanotechnologies and macromolecular agents

Preclinical imaging and translational animal models of cancer for accelerated clinical implementation of nanotechnologies and macromolecular agents

Tumor CT imaging using targeted nanoparticle delivery for contrast enhancement and tumor inhibition using targeted release of carboplatin nanoparticles via radiotherapy

Development of particle induced X-ray emission-computed tomography in Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency

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