Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies

Abstract

In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed a literature review on the studies engaging the usage of gold nanoparticles on murine models with a focus on the type of the carrier, the chemotherapy drug, the target tumoral tissue and outcomes. We identified fifteen studies that fulfilled our search criteria, in which we analyzed the synthesis methods, the most used chemotherapy conjugates of gold nanoparticles in experimental cancer treatment, as well as the improved impact on tumor size and system toxicity. Due to their intrinsic traits, we conclude that chemotherapy conjugates of gold nanoparticles are promising in experimental cancer treatment and may prove to be a safer and improved therapy option than current alternatives.

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

“…As previously described [14][15][16], a systematic search of the PubMed database was performed for all published studies relating to in vivo models of anti-tumor drug delivery via pH-responsive NPs using the following search algorithm: pH AND nanoparticles AND cancer AND delivery AND in vivo. The systematic search was carried out by adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines which were adapted to experimental studies [17].…”

Nanomedicines in Cancer Therapy- An Overview

“…47,48 AuNPs chemotherapy conjugates are studied to implicate effective intracellular drug delivery. 49 Chemotherapy strategized using nanosystems gives an advantage of targeted delivery, overcoming biological barriers and co-delivery of drugs. Solid lipid nanoparticles have also proved to be potent vehicles for the delivery of chemosensitizers and cytotoxic agents.…”